Method for producing L-threonine through fermentation of bacteria changing regulatory element of aconitase

Abstract

The invention provides a method for producing L-threonine through fermentation. The method comprises the steps of transforming the wild type regulatory element of an acnA gene on bacterial chromosome, so that the expression quantity of the aconitase A is lowered, but not disappear; and producing L-threonine through fermentation of the transformed bacteria. In addition, the invention also provides methods and applications derived from the method for producing L-threonine through fermentation, and bacteria used in the methods and applications.

Description

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AI Technical Summary

Benefits of technology

This patented technology allows us to improve the ability of microorganisms (such as yeast) to make specific types of chemicals called 1 - thyrne acid by enhancing their growth rate through adding nitrogen gas into them during culture. By doing this we aimed at improving industrial scale processes where there were previously unknown ways to efficiently produce these compounds without being affected negatively towards economy.

Problems solved by technology

This patented technical problem addressed in this patent relates to improving the efficiency at producing lactate compounds such as α -amino levonutyrans during industrial scale manufacturing processes involving microorganisms like yeast strains.