Application of glucalogue in preparing medicaments for treating or preventing cell death and diseases

A technology of glucose analogs and cell death, which is applied in the field of medicine to achieve good effects, wide application range and the effect of preventing cell death

Inactive Publication Date: 2014-05-21
SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But unfortunately, despite investing a lot of manpower and material resources, there is still no medicine for the treatment or prevention of cell death approved for clinical use.

Method used

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  • Application of glucalogue in preparing medicaments for treating or preventing cell death and diseases
  • Application of glucalogue in preparing medicaments for treating or preventing cell death and diseases
  • Application of glucalogue in preparing medicaments for treating or preventing cell death and diseases

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Embodiment Construction

[0030] The above content of the invention of the present invention will be further described in detail below in conjunction with specific embodiments.

[0031] However, it should not be construed that the scope of the above-mentioned subject matter of the present invention is limited to the following examples. Without departing from the above-mentioned technical idea of ​​the present invention, various replacements and changes made according to common technical knowledge and customary means in this field shall be included in the scope of the present invention.

[0032] This embodiment is the cytological test of 2-fluoro-2-deoxyglucose and 2-deoxyglucose

[0033] This experiment is mainly used to prove that 2-fluoro-2-deoxyglucose (2-FDG) and 2-deoxyglucose (2-deoxyglucose, 2-DG) can protect cells and inhibit cell death.

[0034] Hsp90 (heat shock protein 90) is an intracellular chaperone protein, inhibition of Hsp90 will lead to cell death, 17-AAG is an inhibitor of Hsp90 dev...

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Abstract

The invention relates to the field of medicines, and in particular discloses an application of glucalogue in preparing medicaments for treating or preventing cell death and diseases. Glucalogue is one of 2-deoxyglucose or 2-fluoro-2-deoxyglucose. Furthermore, cell death and diseases are ischemia reperfusion injury, heart diseases, coronary arteriosclerosis, cerebral apoplexy, renal failure or organ failure caused by surgical operations. The medicine is one of local, oral, systematic, intramuscular or intravenous administration preparations, and can further be one of intramuscular injection or intravenous injection. The glucalogue can activate UPR (unfolded protein response) by inhibiting polysaccharide biosynthesis and N-glycosylation, can prevent necrocytosis and apoptosis, and can be used for preparing medicaments for treating various diseases caused by cell death.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to the application of glucose analogues in the preparation of medicines for treating or preventing cell death diseases. Background technique [0002] When cells are severely damaged, they will undergo irreversible changes such as metabolic cessation, structural damage, and loss of function, that is, cell death. Cell death includes two types of necrosis and apoptosis. [0003] Coronary arteries become narrowed due to atherosclerosis, which reduces blood flow to the heart. This condition causes calcium imbalance and free radical production, which in turn causes heart muscle cells to die, leading to arrhythmia and weakening of the heart's pumping Features. Heart disease is caused by blockage of the coronary arteries that supply blood to the heart. Myocardium cells behind the embolism site lose oxygen and nutrient supply due to lack of fresh blood, resulting in myocardial ...

Claims

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Application Information

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IPC IPC(8): A61K31/70A61K31/7004A61P9/00A61P9/10A61P13/12
Inventor 张丰雪
Owner SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL
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