Method for constructing related intestinal canal-pancreatic islet regulation axis function evaluation model and application of model

Abstract

The invention provides a method for constructing a related intestinal canal-pancreatic islet regulation axis function evaluation model. The method includes: allowing a subject to take different oral hypoglycemic drugs or blank control in different stages, then performing intravenous-oral dual hyperglycemic clamp tests on the subject in each stage, drawing an area under the curve for a serum insulin value, a C-peptide value, a plasma glucagon value and an active glucagon-like polypeptide-1 (GLP-1) value acquired through the dual hyperglycemic clamp tests in each stage, and applying Metlab to perform 3D (three-dimensional surface fitting on the areas under the curve in one-to-one correspondence to obtain the related intestine-pancreas axis function evaluation model. By the method, two-phase insulin secretion patterns in intravenous-oral glucose stimulation states can be evaluated and compared accurately, besides, intestinal canal hormone effect and insulin-glucagon secretion can be related quantitatively, and accordingly an accurate intestine-pancreas axis effect model evaluation system is obtained.

Description

technical field [0001] The invention belongs to the field of model construction, and in particular relates to a method and application for constructing a function evaluation model related to the intestinal tract-pancreatic islet regulation axis. Background technique [0002] Some researchers pointed out that under the same blood glucose concentration, the insulin secretion stimulated by oral glucose significantly exceeds the insulin secretion induced by intravenous glucose, and then proposed that these incretins may be related to the regulation of postprandial insulin secretion, and this phenomenon is called "The incretin effect". It mainly refers to the release of peptides secreted by intestinal cells, including glucagon-like polypeptide-1 (GLP-1) and insulinotropic polypeptide (GIP), into the circulation in a glucose-dependent manner, by activating the G protein on the surface of β cells Coupling receptors, increasing the release of cyclic adenosine monophosphate (cAMP), ...

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Problems solved by technology

[0012] The purpose of the present invention is to provide a method for constructing a function evaluation model related to the gut-pancreas axis, aiming at solving the problem that the existing detection technology cannot accurately display the biphasic secretion of insulin stimulated by oral sugar, and thus cannot be compared with that stimulated by simple intravenous sugar. Comparing two phases of insulin secretion leads to inaccurate and incomplete assessment of insulin secretion patterns

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