Application of lycojaponicumin A in the preparation of antibacterial drugs
An antibacterial and drug technology, used in antibacterial drugs, resistance to vector-borne diseases, pharmaceutical formulations, etc., can solve problems such as irritation of the digestive tract and strong accumulation of toxicity
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Embodiment 1
[0012] Embodiment 1: the preparation of the compound Lycojaponicumin A tablet involved in the present invention:
[0013] Take 20 grams of compound Lycojaponicumin A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.
Embodiment 2
[0014] Embodiment 2: the preparation of the compound Lycojaponicumin A capsules involved in the present invention:
[0015] Get 20 grams of compound Lycojaponicumin A, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 tablets.
[0016] The following pharmacodynamic experiments will further illustrate its drug activity.
experiment example
[0017] Experimental example: Antibacterial activity of Lycojaponicumin A
[0018] The antibacterial activity experiment is the method of concentration dilution, and each measurement is repeated three times. The test pathogens include Escherichia coli, Pseudomonas fluorescens, Staphylococcus aureus, Proteus, and Cryptococcus neoformans, and the concentration of the bacteria solution is 10 5 individual / mL. The initial concentration of Lycojaponicumin A is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), and it is serially diluted to 0.098 μg / mL. The bacterial solution and test sample of equal volume are mixed and cultured in a 96-well plate, and the bacterial culture temperature is respectively 37°C, observe after 24 hours of incubation time, if no colonies are found, it is the lowest antibacterial concentration of the sample, that is, the MIC value. The positive control of this experiment is amikacin sulfate, and the antibacterial results of Lycojaponicumin A are shown in Table 1.
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