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Application of lycojaponicumin A in the preparation of antibacterial drugs

An antibacterial and drug technology, used in antibacterial drugs, resistance to vector-borne diseases, pharmaceutical formulations, etc., can solve problems such as irritation of the digestive tract and strong accumulation of toxicity

Active Publication Date: 2015-09-09
FENGJIE DONGYANG BUILDING MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of lycojaponicumin A in the preparation of antibacterial drugs
  • Application of lycojaponicumin A in the preparation of antibacterial drugs
  • Application of lycojaponicumin A in the preparation of antibacterial drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound Lycojaponicumin A tablet involved in the present invention:

[0013] Take 20 grams of compound Lycojaponicumin A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of the compound Lycojaponicumin A capsules involved in the present invention:

[0015] Get 20 grams of compound Lycojaponicumin A, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental example: Antibacterial activity of Lycojaponicumin A

[0018] The antibacterial activity experiment is the method of concentration dilution, and each measurement is repeated three times. The test pathogens include Escherichia coli, Pseudomonas fluorescens, Staphylococcus aureus, Proteus, and Cryptococcus neoformans, and the concentration of the bacteria solution is 10 5 individual / mL. The initial concentration of Lycojaponicumin A is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), and it is serially diluted to 0.098 μg / mL. The bacterial solution and test sample of equal volume are mixed and cultured in a 96-well plate, and the bacterial culture temperature is respectively 37°C, observe after 24 hours of incubation time, if no colonies are found, it is the lowest antibacterial concentration of the sample, that is, the MIC value. The positive control of this experiment is amikacin sulfate, and the antibacterial results of Lycojaponicumin A are shown in Table 1.

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Abstract

The invention relates to application of Lycojaponicumin A in preparation of antibacterial medicaments and belongs to the field of medicine. The Lycojaponicumin A has a strong effect of inhibiting escherichia coli, pseudomonas fluorescens, staphylococcus aureus, proteusbacillus vulgaris and cryptococcus neoformans, so the Lycojaponicumin A can be used as an antibacterial compound and is expected to be applied to preparation of related medicaments. The application of the Lycojaponicumin A in preparation of the antibacterial medicaments is made public for the first time; the skeleton type is completely novel and the Lycojaponicumin A has an unexpectedly strong bacteria inhibiting activity, so the probability that other compounds give any revelation does not exist, outstanding substantive features are provided, meanwhile, prominent improvement is evidently made in prevention and treatment of bacterial infection.

Description

technical field [0001] The present invention relates to the use of Lycojaponicumin A, in particular to the application of Lycojaponicumin A in the preparation of antibacterial drugs. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots. [0003] The compound Lycojaponicumin A involved in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/424A61P31/04
CPCY02A50/30
Inventor 江春平王慧
Owner FENGJIE DONGYANG BUILDING MATERIALS CO LTD
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