Application of fluevirosines A in preparation of monoamine oxidase (MAO) inhibitor
A monoamine oxidase and inhibitor technology, applied in the application field of preparing monoamine oxidase MAO inhibitors, can solve problems such as limited application, and achieve the effect of strong inhibitory activity and outstanding substantive characteristics
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Embodiment 1
[0011] Embodiment 1: the preparation of the compound Fluevirosines A tablet involved in the present invention:
[0012] Take 5 grams of the compound Fluevirosines A, add 195 grams of dextrin, mix well, and conventionally press it into 1000 tablets.
Embodiment 2
[0013] Embodiment 2: the preparation of compound Fluevirosines A capsules involved in the present invention:
[0014] Get 5 grams of compound Fluevirosines A, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.
[0015] The following pharmacodynamic experiments will further illustrate its drug activity.
[0016] Compound Fluevirosines A detects the inhibitory activity to MAO-A and MAO-B with the method of fluorescent probe, and described method is carried out according to the following steps:
[0017] Dissolve the sample to be tested in DMSO to prepare a series of samples with concentration gradient. Take 4ul of MAO (10mg / ml), boric acid buffer (PH=8.4), 50ul of BSA (50mg / ml), add the sample solution to be tested, mix well, react in a water bath at 30-38°C for 3h, and then add probe 7 -(3-Aminopropoxy)coumarin 2ul (50mmol / ml), the final concentration of the inhibitor is 0~10-2mmol / l, and the mixture is reacted in a water bath at 30±5℃ for 12h, an...
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