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Traditional Chinese medicine composition for treating bronchial asthma in remission stage

A technology for bronchial asthma and a composition, applied in the field of traditional Chinese medicine, can solve problems such as adverse reactions, drug dependence or drug resistance, and achieve the effects of improving clinical symptoms, reducing the degree of attacks, and reducing the number of attacks.

Active Publication Date: 2014-06-18
如东县东广物流有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The establishment of the airway inflammation theory makes us not only pay attention to relieve airway smooth muscle spasm and relieve asthma symptoms, but also pay more attention to reducing and eliminating eosinophils in the airway and other mediated inflammatory reactions, so that glucocorticoids In particular, inhaled surface hormones have risen to be the first-line treatment drugs, but excessive dosage may cause hormone-like adverse reactions, and may cause drug dependence or drug resistance

Method used

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  • Traditional Chinese medicine composition for treating bronchial asthma in remission stage

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Effect test

preparation example Construction

[0066] The present invention also provides a preparation method of the above-mentioned traditional Chinese medicine composition, specifically:

[0067] The first step is to mix astragalus, epimedium, psoraleae, gecko, ginseng leaves, ryepogon, Chinese yam, acanthopanax, sand garden seed, ganoderma lucidum, ligustrum lucidum and dendrobium according to their respective weight parts to obtain a mixture, Crush, add distilled water 5 to 8 times the mass of the mixture and decoct for 2 to 4 hours, filter the decoction, add distilled water 2 to 4 times the mass of the mixture and decoct for 2 to 3 hours, filter the decoction, filter Liquids are combined, concentrated under reduced pressure to remove 1 / 2 to 2 / 3 volume of water, add ethanol with an alcohol concentration of 70% to 80% until the proportion of ethanol volume is 60% to 70%, stir while adding, and finish adding Standing for precipitation, taking the supernatant and concentrating under reduced pressure to recover ethanol, c...

Embodiment 1

[0078] Embodiment 1 Granule 1

[0079] Mix 95g of astragalus, 45g of epimedium, 55g of psoralen, 35g of gecko, 65g of ginseng leaves, 45g of Limedong, 55g of Chinese yam, 45g of acanthopanax, 40g of sand garden seed, 45g of ganoderma lucidum, 45g of Ligustrum lucidum and 40g of dendrobium, Obtain the mixture, pulverize it, add 4kg of distilled water to decoct for 3 hours, filter the decoction, add 1.5kg of distilled water to the filter residue and decoct for 3 hours, filter the decoction, combine the filtrates, concentrate under reduced pressure to remove 2 / 3 volume of water, add Ethanol with an alcohol concentration of 80% until the proportion of ethanol volume is 60%, stirring while adding, and standing for precipitation after adding, taking the supernatant and concentrating under reduced pressure to recover ethanol, concentrating to remove the solvent, obtaining a dry paste, crushing into The first powder is 35g ephedra, 30g white mustard seed, 20g loquat leaf, 25g asarum, ...

Embodiment 2

[0080] Embodiment 2 toxicological experiment

[0081] Acute Toxicity Test

[0082] Select 20 Kunming mice, half and half female, body weight (20 ± 2) g, provided by the Qingdao Experimental Animal Center, the granules prepared in Example 1 are dissolved in water, prepared into a 1g / ml solution, and fed Mice, after preliminary experiments, failed to detect orally administered LD 50, so measure its maximum tolerated dose, with the administration volume of 1.4ml / 10g body weight, gavage 2 times / d, interval 6h, observe 7d after administration, record animal death and toxic and side effect symptoms, when experiment finishes, will All animals were processed, dissected, and the lesions of the main organs and tissues were observed with the naked eye. After 2 times of gavage of 140g crude drug / kg, the animals moved, and no abnormalities were found in eating and drinking. The animals died after 7 days of observation, and no major organs were found in the autopsy. Therefore, the maximum...

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Abstract

The invention provides a traditional Chinese medicine composition for treating bronchial asthma in the remission stage. The traditional Chinese medicine composition comprises the following raw materials: radix astragali, ephedra, herba epimedii, fructus psoraleae, semen brassicae, gecko, folium eriobotryae, asarum, tangerine peel, ginseng leaf, fructus gleditsiae sinensis, liriope spicata, Chinese yam, fritillaria cirrhosa, cortex acanthopanacis, knoxia root, negundo chastetree leaf, astragalus complanatus, ganoderma lucidum, conyza blinii, magnolia officinalis, semen coicis, aster, glossy privet fruit, dendrobium nobile and pummelo peel. The traditional Chinese medicine composition provided by the invention has the advantages of being capable of obviously improving the clinical symptoms and signs of the asthma in the remission stage, reducing attack frequency, alleviating attack degree, prolonging attack interval and improving the lung function, thus the asthma is effectively controlled, the survival quality of patients is improved, and the advantages of the traditional Chinese medicine for diagnosing and treating the asthma based on syndrome differentiation are embodied; and compared with the western medicines, the traditional Chinese medicine composition has little toxic and side effects and is low in cost.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating bronchial asthma in remission. Background technique [0002] Bronchial asthma is one of the most common chronic diseases in the world today. There are more than 300 million people suffering from asthma in the world, and there are at least tens of millions of patients in my country. Over the past ten years, the prevalence and mortality of asthma have increased in countries all over the world, especially the United Kingdom, the United States, Australia, and New Zealand. The average prevalence of asthma in my country is 0.5-1.0%, which varies from region to region. In the South, children under the age of 12 are about 2%. The course of disease of many patients is as long as more than ten years to several decades. Therefore, bronchial asthma seriously endangers the health of the broad masses of the people a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61K9/48A61K9/14A61K9/16A61P11/06A61K35/56A61K35/583
Inventor 彭桂花张红刘冰甜万喜超
Owner 如东县东广物流有限公司
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