Method and apparatus for evaluating cardiac function

A technique for cardiac and arrhythmia, applied in the field of computer programs using information provided by electrocardiography, to solve problems such as routine evaluation not being preferred

Active Publication Date: 2015-12-09
UNIVERSITY OF LEICESTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, this is a particularly invasive technique that is not preferred for the routine assessment of subjects and has not been clearly shown to account for any clinical relevance for assessing cardiac function such as the risk of arrhythmia

Method used

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  • Method and apparatus for evaluating cardiac function
  • Method and apparatus for evaluating cardiac function
  • Method and apparatus for evaluating cardiac function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] 1. Embodiment 1: inclusion criteria:

[0099] ●Patients who are being considered for new ICD implantation with NYHA class III-III symptoms of heart failure and documented left ventricular dysfunction.

[0100] 2. Example: Exclusion Criteria

[0101] ●Unstable coronary artery disease, which may require percutaneous or surgical intervention

[0102] ●Requirement for sustained cardiac pacing (eg, high-grade AV block or for cardiac resynchronization)

[0103] ●Recent coronary artery bypass surgery (within 3 months)

[0104] ●Recent valve surgery (within 3 months)

[0105] ●Recent myocardial infarction (if documented by appropriate ECG and biochemical analysis) (within 3 months)

[0106] 2.1 Main outcome measure: ICD therapy for ventricular arrhythmia or death during 2-year follow-up period

Embodiment 3

[0107]3. Example 3: A study of patient practices incorporated after the analysis from Examples 1 and 2

[0108] A) Subjects were divided into two groups studied in the post-absorption state (the first group were patients determined to be at high risk of arrhythmia; the second group were patients determined to be at low risk of arrhythmia ).

[0109] B) Proper aseptic technique is used throughout the process.

[0110] C) Skin ECG leads are applied in standard locations and connected to a suitable electrophysiological recorder. (Bard system used to study standard 12-lead ECG locations)

[0111] D) Select the appropriate transvenous route and insert the 6F venous sheath using the Seldinger technique.

[0112] E) A suitable electrophysiology catheter, such as a 6F Josephson tetrode catheter, is sheathed.

[0113] F) Steering the catheter into the right ventricular apex using fluoroscopic guidance, obtaining a stable position in the right ventricular apex.

[0114] G) Obtainin...

Embodiment 4

[0120] 4. Example 4: Pilot Study Using Regional Repolarization Instability Index on Myocardial Heterogeneity and Prediction of Ventricular Arrhythmias and Death

[0121] 4.1 Method

[0122] 4.1.1. Subjects have undergone programmed electrical stimulation (PES) between January 1, 2005 and July 31, 2009 by screening the departmental audit database as a clinical risk stratification for ICD implantation Patients with a history of IHD who were part of the IHD and had had a CMR scan within 6 months of their PES were identified. This identified 43 patients. PES recording was not available for 9 patients and an additional 4 patients were excluded because only 6 lead ECGs had been recorded. Of the 30 patients whose PES data were available, 1 could not be analyzed because their drive loop length (DCL) was changed midway through the protocol. The CMR data of these 30 patients are then sought. LGE images for 3 patients were not acquired due to difficulties with gating (1) and breath...

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Abstract

The present invention relates to a method for assessing the electrical function of a heart, comprising the steps of:-(1) for each of a plurality of leads of an ECG, determining a value derived from the output of that lead and which corresponds to an action potential duration; (2) for each of the plurality of leads of the ECG, determining a value derived from the output of that lead and which corresponds to a diastolic interval; (3) for each of the plurality of leads of the ECG, determining a relationship between the determined values for action potential duration and for diastolic interval; (3) assessing the differences between the determined relationships for each of the plurality of leads. The invention further relates to apparatus and a computer program that may be used in the method.

Description

technical field [0001] The present invention relates to methods for evaluating cardiac function, in particular using information provided by electrocardiography. The invention also relates to a device, including a computer program, in which the above-mentioned method can be practiced. Background technique [0002] The heart's inherent conduction system allows electrical impulses originating from the sinoatrial node to travel through the heart tissue in a controlled manner. Passage of this electrical pulse through the cardiac tissue produces a wave of contraction through the cardiac tissue. The wave of contraction is followed by a period of relative electrical calm in the cardiac tissue, which corresponds to relaxation of the cardiac tissue. Arrhythmias occur when this normal organized electrical activity of the heart is disrupted. Worldwide, 3 million people die of sudden cardiac death every year. In most cases there is no warning and the heart is stopped by a sudden arr...

Claims

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Application Information

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IPC IPC(8): A61B5/0464A61B5/361A61B5/363A61B5/364
CPCA61B5/046A61B5/04012A61B5/0464A61B5/363A61B5/361A61B5/364A61B5/36
Inventor 威廉姆·尼科尔森安德烈·G·恩吉
Owner UNIVERSITY OF LEICESTER
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