Compositions for topical administration

Abstract

The invention provides a composition comprising benzoyl peroxide or derivative thereof; and at least one antibiotic compound selected from pseudomonic acid, retapamulin, fusidic acid and derivatives thereof; methods and uses of a composition of the invention in the treatment of at least one topical disease or disorder and kits comprising a composition of the invention.

Description

technical field [0001] The present invention relates to compositions and kits comprising benzoyl peroxide or derivatives thereof and at least one antibacterial and / or antimicrobial agent. Background technique [0002] As the use of conventional medicinal antibiotics for medical, veterinary and agricultural purposes has increased, there has been a parallel emergence of antibiotic resistant strains of pathogenic bacteria. [0003] The emergence of single-drug or multidrug-resistant bacteria may result from genetic modifications that respond to selection pressures associated with antibiotic use. In recent decades, the increasingly frequent use of antibiotics has acted synergistically with the generation of spontaneous mutations in the bacterial gene pool to generate distinct bacterial strains that are insensitive to current antibacterial treatments. [0004] Gram-positive bacteria are a major cause of nosocomial infections. The most common pathogenic isolates in hospitals inc...

AI Technical Summary

Problems solved by technology

Thus, the presence of resistant bacteria (e.g., VRE) in hospitals not only poses a risk of infection, but also the continued evolution of resistant organisms (e.g., more virulent organisms such as VR-MRSA)

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