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Human milk permeate compositions and methods of making and using same

A technology of permeate and composition, applied in the field of human milk permeate composition, can solve the problems of changes in nutritional value, insufficient to meet the needs of premature infants, bacteria, viruses and other contamination of donor raw milk

Inactive Publication Date: 2011-12-28
PROLACTA BIOSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the nutritional value of raw or conventionally processed donor milk varies and in most cases is insufficient to meet the needs of preterm infants
In addition, there is the potential for bacterial, viral and other contamination of donor raw milk

Method used

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  • Human milk permeate compositions and methods of making and using same
  • Human milk permeate compositions and methods of making and using same
  • Human milk permeate compositions and methods of making and using same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1: Collection and Analysis of Human Milk Permeate

[0059] Human milk was collected from screened donors throughout the United States and stored at -20°C for up to 12 months. Pooled donor human milk was processed and analyzed for oligosaccharide composition on multiple samples. A pool from 20-50 donors was used to generate the human milk fortifier composition described in application U.S.S.N. 11 / 947,580.

[0060] Prior to processing, a sample of the initially pooled donor milk was set aside for analysis (sample 49 in Table III). The combined milk is screened, filtered, heat treated, separated into skim milk and milk fat, and the skim milk is ultrafiltered. The filtrate composition, a portion of the permeate, was set aside for analysis (sample 53 in Table IV). The skim milk is mixed with the cream and pasteurized. A portion of the final product batch was set aside for analysis (samples 42, 48, and 54 in Tables I, II, and V, respectively).

[0061] Each mil...

Embodiment 2

[0085] Example 2: Oligosaccharide profiles of pooled permeate samples

[0086] Six pooled permeate samples were analyzed for specific oligosaccharide content (Table VI). Each pooled permeate sample was derived from pooled milk received from multiple donors by the method discussed in Example 1 above. Collected samples of the permeate were analyzed by mass spectrometry by the method described in Example 1 above to detect the presence (1) or absence (0) of the specific oligosaccharides indicated. Oligosaccharides are represented in Table VI by their mass / charge ratios.

[0087] Table VI

[0088]

[0089] 1 = Oligosaccharides present in the sample

[0090] 0 = No oligosaccharides detected in the sample

[0091] It appears that although there is overlap between the samples with respect to some oligosaccharides (ie oligosaccharides 732, 878, 1097, 1243 and 1389 are present in all six samples), there are also Many of the oligosaccharides in (ie, oligosaccharide 935 were p...

Embodiment 3

[0092] Example 3: Application of Permeate Composition

[0093] As discussed above, the inventors believe that human milk permeate compositions from pooled milk can provide a wide variety of nutritional and immunological benefits because they are a source of a greater variety of oligosaccharides than are found in individual breast milk . They can also contain various types of peptides and other beneficial small molecules.

[0094] The isolated human milk permeate composition will be administered to infants (both preterm and term infants) to promote their proper gut flora, ameliorate and / or eliminate infections. The study will investigate infants divided into 5 arms (arms), each arm consisting of infants who receive:

[0095] 1. Breast milk fortifier

[0096] 2. Milk plus permeate

[0097] 3. Milk plus Bifidobacterium strain 1

[0098] 4. Milk plus Bifidobacterium strain 2

[0099] 5. Milk plus fructo-oligosaccharides from non-dairy sources

[0100] The composition of t...

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Abstract

The present disclosure features human milk permeate obtained from fractionated whole human milk and compositions containing the human milk permeate. The oligosaccharide-rich permeate and permeate composition of the present invention can be used as a nutritional supplement for premature and full-term infants to establish or maintain intestinal flora and to treat symptoms of inflammatory bowel disease.

Description

[0001] Inventors: Joseph Fournell, Scott Eaker, Scott Elster, David J. Rechtman [0002] This application claims priority to US Provisional Application No. 61 / 193,546, filed December 5, 2008, and US Provisional Application No. 61 / 119,176, filed December 2, 2008, both of which are incorporated herein in their entirety. technical field [0003] The present disclosure relates to human milk permeate compositions, such as compositions comprising human milk oligosaccharides, and methods of making and using such compositions. Background of the invention [0004] Human milk is generally the food of choice for preterm and term infants due to its nutritional composition and immunological benefits. The source of human milk can be, for example, the donor or the mother of the infant. However, the nutritional value of raw or conventionally processed donor milk varies and in most cases is insufficient to meet the needs of preterm infants. In addition, there is the possibility of bacteria...

Claims

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Application Information

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IPC IPC(8): A61K35/20A23C9/14A23C9/15A23L33/00
CPCA61K35/20A23C9/148A23C9/1422A23L1/296A23V2002/00A23C9/206A23L33/40A61P1/00A61P1/04A61P29/00A61P3/02A23V2250/28A23V2200/3202A23C3/02A23C9/1427A23C9/1522A23C9/158
Inventor J.福尔尼尔S.埃克S.埃尔斯特D.J.雷克特曼
Owner PROLACTA BIOSCI
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