Device and method for detecting diseases by using DNA library

Abstract

The invention discloses a device and a method for detecting diseases by using a DNA library. The device comprises reaction module at least preset with male sterility DNA library sequence information, a signal reaction detection module and a processor module preset with state information, wherein the reaction module, the signal reaction detection module and the processor module are connected with one another; the reaction module is used for reacting with a DNA sample to be detected; the signal reaction detection module detects the state information of the reaction and feeds the state information back to the processor module; and the processor module performs analysis according to the fed back state information and the preset state information. By using the device and the method, the male reproductive health level and genetic risks can be detected and evaluated with high flux by using the latest genetic information, the male reproductive health and the genetic background can be evaluated scientifically to make a decision of a reproductive mode so as to prevent genetic defects from being inherited to the next generation.

Description

technical field [0001] The invention relates to a device and method for detecting diseases. Background technique [0002] Worldwide, male infertility has become a major reproductive health problem, affecting approximately 15% of couples. In the United States, about every six couples of childbearing age, there is one infertile couple, the number exceeds 6.1 million, and 30-50% of them are caused by male infertility. In my country's urban population of childbearing age, the incidence of infertility accounts for 10%, while in rural areas it accounts for 15%. According to the information provided by "Health Daily" on November 4, 2000, there are 35 million male infertility patients in my country. In Africa, male infertility is as high as 30%. The World Health Organization announced that infertility, alongside cardiovascular disease and tumors, has become one of the three major diseases that affect human life and health today. [0003] Male infertility is mainly caused by asth...

AI Technical Summary

Problems solved by technology

Chromosomal abnormalities and Y chromosome microdeletions can be easily detected by conventional karyotype analysis and polymerase chain reaction (PCR) techniques, but high-throughput detection of multiple gene mutations and single nucleotide polymorphisms (SNP), there is currently a lack of accurate and effective processing and analysis systems

At the same time, there is currently no treatment for azoospermia in male infertility. Such patients cannot obtain their own biological offspring, and can only obtain their nominal children through sperm donation and adoption.

Although about 40% of patients with asthenozoospermia and oligospermia can obtain their own biological offspring through assisted reproductive technology (ART), the gene mutation or SNP carried by the patient is passed on to the next generation through assisted reproductive methods, which can cause their offspring Male infertility and other unpredictable genetic risks also occur

At present, there is no device and implementation method for high-throughput detection and evaluation of male reproductive health and genetic risk using the latest genetic information, so as to scientifically evaluate male reproductive health and genetic background, and prevent hereditary defects from being passed on to others. next generation

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