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Porous biological assay substrate and method and device for producing such substrate

A biological assay and substrate technology, applied in the field of analyzing biological sample fluids, can solve the problems that the fluorescent pattern cannot be clearly distinguished, the indicator factor is missed, etc., so as to reduce the analysis time, improve the detection limit, and increase the analysis time.

Inactive Publication Date: 2009-09-16
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When molecules bind (or hybridize in the case of DNA strands) insufficiently, certain indicator factors may be missed and / or the fluorescent pattern may not be clearly distinguished and / or is defective in some other sense

Method used

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  • Porous biological assay substrate and method and device for producing such substrate
  • Porous biological assay substrate and method and device for producing such substrate
  • Porous biological assay substrate and method and device for producing such substrate

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Embodiment Construction

[0023] The present invention will be described by means of particular embodiments and with reference to certain drawings but the invention is not limited thereto but only by the claims. Any reference signs in the claims should not be construed as limiting the scope. The drawings described are only schematic and non-limiting. In the drawings, the size of some of the elements is exaggerated and not drawn on scale for illustrative purposes. Where the term "comprising" is used in the present description and claims, it does not exclude other elements or steps. Where a definite or indefinite article is used when referring to a singular noun such as "a", "an" or "the", this includes a plurality of that noun unless something else is specifically stated.

[0024] Furthermore, the terms first, second, third etc. used in the description and claims are used to distinguish similar elements, but not necessarily to describe a sequential or chronological order. It is to be understood that ...

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Abstract

The invention provides a porous biological assay substrate suitable for detecting at least one analyte in a biological sample fluid. The substrate comprises one or more capture probes able to each specifically bind one target analyte. The average concentration of the capture probes in pores with a size larger than the O50 of the substrate pore size distribution is at least equal to the average concentration of the capture probes in pores with a size smaller than the O50. The substrate thereby shows improved binding efficiency. The invention also relates to a method and device for producing the biological assay substrate, and to a method for examining analyte fluids using the substrate.

Description

technical field [0001] The present invention relates to the field of analyzing biological sample fluids for certain analytes, and in particular to porous bioassay substrates suitable for detecting at least one analyte in a biological sample fluid. In particular, the invention allows accurate and efficient analysis of biological sample fluids. The invention further relates to a method for producing a bioassay substrate by depositing substances onto the substrate, and to a bioassay substrate obtainable by this method. The invention also relates to a method for analyzing a sample fluid for one or more analyte molecules present in the sample fluid. The analyte may include any compound capable of binding to a capture probe on a substrate, including target biological compounds, proteins, DNA, and the like. The method can be used in molecular diagnostic assays, for example to measure the presence of pathogens and resistance genes for infectious diseases. Background technique [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53
CPCG01N33/54386G01N33/5436
Inventor R·库特J·F·迪克斯曼A·皮里克
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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