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Contrast agent for MR cholangiopancreatography

A contrast agent and magnetic resonance technology, applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agent, etc., can solve the problems of high price, affecting the observation of pancreaticobiliary duct, and reducing the high signal of gastrointestinal fluid

Inactive Publication Date: 2010-06-09
济南市第四人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned two kinds of oral contrast agents have following deficiencies: 1. special-purpose Gd-DTPA oral liquid can obviously reduce gastrointestinal fluid hyperintensity, and mouthfeel is better, there is no adverse reaction after taking, but this method cost increases, so increases the number of patients 2. Iron-containing contrast agents have their contraindications (iron allergy, gastrointestinal perforation, high obstruction, hyperferremia, pregnant women and infants), and ingestion of high-concentration iron-containing contrast agents can cause nausea , severe vomiting, abdominal pain, diarrhea and other gastrointestinal discomforts. In addition, the stool is black after administration, and false positives for occult blood may occur; 3. The mechanism of action of barium sulfate suspension (BaSO4) suspension and paramagnetic contrast agent Similarly, oral administration of 500 mL of BaSO4 suspension with a concentration ratio (W / V%) of 50% once, followed by MRCP scanning 20 minutes later to ensure that the contrast agent has entered the duodenum, can better suppress the high signal of fluid in the gastrointestinal tract
Through experiments, barium is very prone to stratification, and when there is a lot of fluid retention in the stomach of the subject, the effect of barium on the water signal in the gastrointestinal tract is not good, which affects the observation of the pancreaticobiliary duct; 4. Pineapple juice and Blueberry juice, the price is more expensive, the source is not very wide

Method used

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  • Contrast agent for MR cholangiopancreatography
  • Contrast agent for MR cholangiopancreatography
  • Contrast agent for MR cholangiopancreatography

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A contrast agent for magnetic resonance cholangiopancreatography, which is tea water with a manganese concentration of 5 mg / L.

[0041] The production method is as follows: pour 200ml of boiled water into a beaker containing 4g of Pu'er tea, shake it intermittently for 5 times, and after about 30 minutes, add the upper layer solution, which is tea.

[0042] Instructions: After 12 hours of fasting, the subjects took 200ml of the above-mentioned tea orally, at a rate of about 200ml / min, and checked after about 20 minutes.

[0043] The outline of pancreaticobiliary duct after MRCP scanning is more clearly delineated than conventional MRCP.

Embodiment 2

[0045] A contrast agent for magnetic resonance cholangiopancreatography, which is tea water with a manganese concentration of 12.04±0.2mg / L.

[0046] The production method is as follows: pour 300ml of boiled water into a beaker filled with 10g of Rizhao green tea, shake it intermittently for 3 times, and after about 20 minutes, add the upper solution, that is, tea.

[0047] Instructions: After 12 hours of fasting, the subject takes orally 300ml of the above-mentioned tea at a speed of about 300ml / min, and checks after about 10 minutes.

[0048] After MRCP scanning, the image is very clear Figure 4 .

Embodiment 3

[0050] A contrast agent for magnetic resonance cholangiopancreatography, which is tea water with a manganese concentration of 13 mg / L.

[0051] The production method is as follows: pour 400ml of boiled water into a beaker containing 16g of rose tea, shake it intermittently for 3 times, and after about 20 minutes, add the upper layer solution, which is tea.

[0052] Instructions: After 12 hours of fasting, the subject takes orally 400ml of the above-mentioned tea at a rate of about 300ml / min, and checks after about 10 minutes.

[0053] The image after MRCP scan is very clear.

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Abstract

The invention provides a contrast agent for magnetic resonance cholangiopancreatography use, which is tea water, the manganese concentration of which ranges from 5mg / l to 13mg / l. In the invention, thetea water used as the contrast agent has good taste, stable structure in human body, no changes to gastrointestinal system functions, high security factor, nontoxicity, good relaxation, no fermentation in intestinal cavum and no gas generation, and the intestinal cavum is fully filled with the tea water to ensure uniform signals in the intestinal cavum. The tea water has high solubility, low cost, wide sources, easy acceptability for sufferers, low concentration for orally taking without any obvious discomfort, nausea, vomiting and constipation, and the application of the contrast agent is realized by requiring no drug test; disease diagnosis can be realized by drinking the tea water, which is more acceptable for patients compared with chemical medicines. Furthermore, the application of the contrast agent is realized by requiring no drug test, thus greatly reducing the diagnosis charges of the patients.

Description

technical field [0001] The invention relates to the technical field of reagents for medical detection, in particular to a contrast agent for magnetic resonance cholangiopancreatography. Background technique [0002] Due to the wide range and degree of pancreaticobiliary disease, the clinical manifestations are very complicated, which brings difficulties to clinical diagnosis. In the past, the main basis for diagnosis was endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous hepatic cholangiography (PTC). However, ERCP and PTC are invasive examinations, especially unsuitable for patients with biliary system infection and biliary obstruction in the elderly, which are far from meeting clinical requirements. [0003] Magnetic resonance cholangiopancreatography (MRCP) is a non-invasive examination technique developed rapidly in recent years and widely used in clinics to display the pancreaticobiliary duct. Its principle is to use the long T2 characteristic of wat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06
Inventor 景传博韩庆森开治国刘继鹏亓进友郭君
Owner 济南市第四人民医院
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