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2-chitose-salicylic acid graft compound and its preparing method

A technology of salicylic acid and chitosan, which is applied in the field of 2-chitosan·salicylic acid graft compound and its preparation, can solve the problems of gastric perforation, cannot be directly taken orally, strong irritation of salicylic acid, etc. Conducive to plant absorption, comprehensive effect improvement, obvious effect

Inactive Publication Date: 2008-12-17
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, salicylic acid (SA) has a strong irritant and cannot be taken orally directly. Long-term use will bring different degrees of gastric irritation to patients, and even cause gastric perforation.

Method used

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  • 2-chitose-salicylic acid graft compound and its preparing method
  • 2-chitose-salicylic acid graft compound and its preparing method
  • 2-chitose-salicylic acid graft compound and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, chitosan (deacetylation degree 92%) and salicylic acid are fed into the reaction flask by the weight of 5: 3.5, add 10 times of ethanol, stir and react at 60°C for 2.0hr, reclaim the solvent, and use ethanol Reflux to elute unreacted salicylic acid to obtain 2-position CTS-g-SA grafts, with an average grafting rate of 60% to 70%.

Embodiment 2

[0035] Example 2. Chitosan (95% degree of deacetylation) and salicylic acid were fed into the reactor at a weight ratio of 6:1.5, and ground for 2 hours. Add 30 times of ethanol to do entrainer azeotropic distillation. Suction filtration, washing unreacted salicylic acid with ethanol to obtain 2-position CTS-g-SA grafts, with an average grafting rate of 20% to 30%.

Embodiment 3

[0036] Embodiment 3, 3g chitosan is put in the reactor; Get 2.6g salicylic acid and dissolve with the ethanol-benzene mixed solution of 100ml volume ratio 9: 1, this solution is added in the reactor, reflux 0.5hr under stirring, The solvent was evaporated. The solid was washed with ethanol to obtain a 2-position CTS-g-SA graft, with an average graft ratio of 70% to 75%.

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Abstract

2-chitosan salicylic acid graft compound and its preparation method, chitosan (monosaccharide unit) and salicylic acid are added to the reactor at a weight ratio of 10:1-1:2, and the amount of feed 3-50 times (W / V) dispersant, isolated after 1-3hr reaction at 0-100°C. The dispersant is alcohol, ether, alcohol-benzene mixed solvent or aprotic polar solvent. It can be obtained by stirring and reacting chitosan and salicylic acid at a temperature of 30-80 ° C, and using ethanol as a solvent to reflux the reactant or washing it until it does not contain free salicylic acid. It can also be obtained by making chitosan Sugar and salicylic acid are reacted in solid phase at room temperature for 1-3 hours, and the obtained solids are heated and dehydrated at 50°C-100°C or azeotropically distilled with an entrainer. The dehydrated product is extracted with ethanol as a solvent reflux or washed until no Contains free salicylic acid. The azeotropic distillation entrainer is ethanol, benzene or ethanol-benzene mixture. After grafting, the advantages of the two raw materials are complementary, the performance is greatly improved, and the comprehensive effect is obviously improved.

Description

technical field [0001] The invention relates to a 2-chitosan·salicylic acid graft compound and a preparation method thereof. Background technique [0002] Chitin is one of the most abundant natural polymer compounds on the earth, and its annual biosynthesis is estimated to reach as much as 10 billion tons, which is enough to rival the annual output of cellulose. A large number of research results show that chitin and its derivatives are used for growth inhibitors of agricultural plant pathogens, plant disease resistance inducers, nematicides, seed treatment agents, fertilizers and soil improvers, and fruit and vegetable preservation due to their unique crop mechanism. Agents, food preservatives, etc. are important resources for the production of pollution-free agricultural products. At the same time, because of its antibacterial, anti-inflammatory and cell repairing functions, it has also been used in the pharmaceutical industry to a certain extent. Chitosan (CTS, including...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08
Inventor 侯益民武雪芬
Owner HENAN UNIV OF CHINESE MEDICINE
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