Intravascular Tissue Disruption

Abstract

Disrupting tissue and devices and systems for disrupting tissue. The disclosure describes ways to deliver moieties to a target tissue, where the target tissue in general is not at the point of introduction, in such a way that minimal damage is produced in the tissue at the point of introduction. In some embodiments this is accomplished by jetting fluid at high velocity into the target tissue. The disclosure further describes novel agents deliverable in such systems for use in remodeling tissues. Some of these agents comprise a liquid while others do not. Additionally, although not specifically described in detail much of the disclosure may additionally be used in the delivery of therapeutic drugs.

Description

CROSS-REFERENCE[0001]This application is a continuation of pending U.S. Application Ser. No. 13 / 071,436, filed Mar. 24, 2011, which claims the benefit of U.S. Provisional Application No. 61 / 317,231, filed Mar. 24, 2010, and U.S. Provisional Application No. 61 / 324,461, filed Apr. 15, 2010, the disclosures of which are incorporated herein by reference in their entirety.BACKGROUND OF THE INVENTION[0002]Various treatments to bodily tissue have been attempted. Devices that can deliver a fluid from a distal end port of a catheter have been described. Devices have been described that have a valve at a distal port that allows fluid to flow through the valve in an open configuration and prevents fluid from flowing through the valve in a closed configuration. Devices have also been described that can create microfluidic pulsed jets at the distal end of a catheter. Additionally, intravascular devices that include elements that pierce lumen walls can be deployed within a lumen and deliver medic...

AI Technical Summary

Benefits of technology

[0007]In some embodiments delivering a fluid agent from the delivery device through the lumen wall comprises delivering the fluid agent towards neural tissue peripheral to an intimal layer of the lumen. In some embodiments damaging comprises damaging renal nerve tissue peripheral to a lumen of a renal artery. In some embodiments damaging renal nerve tissue reduces hypertension.

[0009]In some embodiments the fluid control has a closed configuration and an open configuration, wherein in the closed configuration a substantially smaller volume of fluid, such as no fluid, is allowed to be released out of the fluid control than in the open configuration. In the open configuration the fluid control can be adapted to release the fluid at high velocity. In some embodiments the distal region comprises a plurality of fluid controls in fluid communication with the lumen, each fluid control has open and closed configurations, and wherein each fluid control is adapted to regulate the volume of fluid that is released from the fluid control when the fluid is delivered at high velocity. The plurality of fluid controls can be adapted to be individually opened. In some embodiments the fluid control is adapted to be in fluid communication with a fluid source maintained at a substantially constant pressure. The fluid control can control the volume of fluid that is released from the fluid control while the fluid source is maintained at the substantially constant pressure.

Problems solved by technology

In some embodiments damaging comprises damaging tissue with the direct mechanical interaction of the fluid.

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