Containers for reducing or eliminating foaming

Abstract

A foam reducing or eliminating container for containing a liquid includes: a container body having a top portion, a bottom portion and an opening for adding a liquid to or removing a liquid from the container body; and a hollow baffle located within the container with first and second openings therein. The first and second openings are covered with a pierceable seal, wherein the first opening of the baffle is at least partially aligned with the opening of the container. In a preferred embodiment, the container is a reagent supply container for an automated analyzer, which includes: a container as described above; and a closure which is movable away from the opening of the container to be in an open position and movable into contact with the opening to be in a closed position. In another preferred embodiment a reagent supply for an automated analyzer includes: the reagent supply container as described above; and a liquid reagent therein. The second opening of the baffle is submerged in liquid. A method for reducing or eliminating the aspiration of foam into a metering probe includes: providing a reagent supply as described above; providing a metering probe movable in a direction toward and away from the reagent supply; moving the closure away from the opening of the container; piercing both seals covering the first and second openings of the baffle allowing liquid to enter the baffle from the end of the baffle submerged in the liquid, wherein the seals may or may not be pierced with the metering probe; moving the metering probe into the first opening of the baffle and into contact with the liquid in the baffle; aspirating a selected amount of liquid in the baffle; and moving the metering probe out of the baffle.

Description

BACKGROUND OF THE INVENTION [0001] The present invention relates to reducing or eliminating foaming in a liquid containing container, particularly where the liquid is removed from the container. In particular, the present invention relates to a reagent supply or pack for use on an automated analyzer, which reduces or eliminates foaming. [0002] Known diagnostic analyzers include immunodiagnostic and clinical chemistry analyzers such as the Vitros® ECi immunodiagnostic analyzer, sold by Ortho-Clinical Diagnostics, Inc. These types of analyzers include a source of reagents for carrying out various tests. Most often, the reagents are stored in containers having removable closures in which a metering probe can be inserted to aspirate a reagent in the container. For example, a reagent pack container as shown in FIG. 1 is used on the Vitros® ECi immunodiagnostic analyzer, sold by Ortho-Clinical Diagnostics, Inc. In the containers, such as those shown in FIG. 1, a Surlyn® seal is at the top...

AI Technical Summary

Benefits of technology

[0012] According to yet another aspect of the invention, there has been provided a method for reducing or eliminating the aspiration of foam into a metering probe. The method includes: providing a reagent supply as described above; providing a metering probe movable in a direction toward and away from the reagent supply; moving the closure away from the opening of the container; piercing both seals cover...

Problems solved by technology

However, aspirating from the bottom of the container can cause increased metering imprecision.

In addition, while the small diameter and geometry of the non-disposable reagent metering probe (also known as a proboscis) enables aspiration from the bottom of the reagent pack, the trend in modern analyzers is to use a disposable tip which makes it much more difficult to aspirate from the bottom of the reagent container because of the size of the tip and the need to minimize the wetted depth of the tip.

Since the tip cannot be inserted very far into the liquid, there is the significant possibility that the metering probe will aspirate foam instead of pure reagent liquid.

None of the known art described above, adequately addresses resolving the problems described above, in particular, preventing or reducing the aspiration of foam into a metering probe.

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