N-acyl amino glucose and its preparation process
A technology of glucosamine hydrochloride and acyl amino, which is applied in the field of acylation of glucosamine, and can solve problems such as aggravation of diabetes and gout, facial flushing, and ulcer induction
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[0019] Take 2-deoxy-2-nicotinamide-β-D-glucose and its preparation method as an example:
[0020] The molecular structural formula of 2-deoxy-2-nicotinamide-β-D-glucose is:
[0021]
[0022] Its whole reaction process is expressed as follows:
[0023]
[0024]
[0025] 1. Synthesis of Nicotinyl Chloride Hydrochloride
[0026] 3-15.0ml SOCl 2 Put it into the reaction flask equipped with HCl gas absorption device, add 0.4∽15g nicotinic acid to it at about -10∽5℃, stir, drop a few drops of anhydrous DMF, and slowly raise the temperature to 60∽85℃ in an oil bath , after reflux for 3h, the excess SOCl was distilled off under reduced pressure 2 , to obtain light yellow powdery solid substance (1) with a yield of 81%.
[0027] 2. Synthesis of 1,3,4,6-tetraoxyacetyl-2-deoxy-β-D-glucosamine hydrochloride
[0028] React quantitative glucosamine hydrochloride in 30∽80mL dilute NaOH solution with 2.5g p-methoxybenzaldehyde for 1∽4h. After filtering, washing and drying, N-p-m...
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