Construction method and application method of lung cancer prognosis model and electronic equipment

Abstract

The invention discloses a construction method and an application method of a lung cancer prognosis model, electronic equipment and a storage medium. The construction method comprises the following steps: acquiring peripheral blood leukocyte transcription spectrum expression data of a plurality of lung cancer patients and a plurality of reference people; screening candidate genes based on the transcriptional profile expression data; constructing a risk scoring model based on the candidate genes; wherein a lung cancer prognosis model comprises a risk scoring model; screening candidate genes based on the transcriptional profile expression data, including: performing similarity analysis on the transcriptional profile expression data to determine a plurality of lung cancer subgroups; respectively carrying out differential expression gene analysis on the plurality of lung cancer subgroups and a plurality of reference people, and determining respective differential expression genes of the plurality of lung cancer subgroups; comparing the expression states of the differentially expressed genes of the plurality of lung cancer subgroups, and selecting the lung cancer subgroup with more immunosuppressive genes in a high expression state from the plurality of lung cancer subgroups as a candidate lung cancer subgroup; and screening candidate genes from the differentially expressed genes of the candidate lung cancer subgroups.

Description

technical field [0001] Embodiments of the present disclosure relate to a construction method and an application method of a lung cancer prognosis model, an electronic device, and a storage medium. Background technique [0002] Prognosis refers to the empirical prediction of disease progression. Prognosis involves three main areas, what will happen, the likelihood of an adverse outcome, and when. The purpose of researching and rating prognosis is to facilitate the understanding of the degree of harm of diseases to human beings, to explore the factors affecting prognosis, and to study specific measures to improve prognosis. Prognosis analysis is a clinical research that is very practical and instructive. [0003] Lung cancer (LC) is a highly heterogeneous disease with poor prognosis and high mortality, ranking first among the causes of cancer death worldwide. Currently, the treatment and prognosis of lung cancer patients are mainly based on the Tumor-Node-Metastasis (TNM) s...

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Problems solved by technology

However, most studies are based on the characteristics of tumor tissue, ignoring the limitations of intratumoral heterogeneity and sampling bias on the effectiveness and wide application of the screened prognostic markers.

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