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A kind of artificial bone repair material with osteogenic activity and mechanical support performance and its preparation method and application

A repair material and osteogenic activity technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve problems such as inability to flexibly control the composite ratio of inorganic active materials, limited composite ratio of inorganic active materials, and failure to meet the use requirements , to achieve the effects of regular surface structure, high degree of bonding and improved mechanical properties

Active Publication Date: 2022-05-24
北京德得创业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, we found in the process of practical application that although attaching inorganic materials to the surface of biological bone can effectively increase the mechanical properties of the material, the high-temperature composite operation will greatly remove the inorganic mineral components inside the biological bone itself and damage its mechanical properties. , to offset part of the mechanical properties brought by the active materials, so that the mechanical properties of the final composite inorganic material bio-bone scaffolds are only slightly higher than those of the untreated bone scaffolds, without significant improvement, which is far below the clinical requirements. Requirements for the use of supporting structures for bone tissue repair
[0007] In addition, although the above method can effectively increase the osteogenic activity of the material by compounding osteogenic active ingredients into biological bone, there is also a limitation in the compounding ratio of inorganic active materials, and it is impossible to flexibly control the compounding ratio of inorganic active materials to meet different needs. Application requirements and other issues

Method used

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  • A kind of artificial bone repair material with osteogenic activity and mechanical support performance and its preparation method and application
  • A kind of artificial bone repair material with osteogenic activity and mechanical support performance and its preparation method and application
  • A kind of artificial bone repair material with osteogenic activity and mechanical support performance and its preparation method and application

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Effect test

Embodiment 1

[0040] The present embodiment provides a method for preparing an artificial bone repair material, comprising the following steps:

[0041] (1) Take natural pine beef bone, prepare a long strip structure of 1cm*1cm*2cm, remove blood fat and bone marrow and other components and rinse fully, and then use hydrogen peroxide ultrasonically soaked for 90min to further remove fat components, soaked in absolute ethanol for 30min to further inactivate the virus components, and then further cleaned with surfactant in water and dried, to obtain natural biological bone scaffold material backup;

[0042] (2) According to the quality score, the SiO will be 2 45％，CaCO 3 25％，Na 2 CO 3 20％，P 2 O 5 5％，MgCO 3 5% well mixed, calcined at high temperature at 1200 °C, and kept at a stable temperature for 5h to form a stable molten state bioactive material;

[0043] (3) The natural biological bone scaffold material prepared in step (1) is fixed with a high-temperature resistant ceramic material, and its v...

Embodiment 2

[0048] The present embodiment provides a method for preparing an artificial bone repair material, comprising the following steps:

[0049](1) Take natural pine beef bone, prepare a long strip structure of 1cm*1cm*2cm, remove blood fat and bone marrow and other components and rinse fully, and then use hydrogen peroxide ultrasonically soaked for 90min to further remove fat components, soaked in absolute ethanol for 30min to further inactivate the virus components, and then further cleaned with surfactant in water and dried, to obtain natural biological bone scaffold material backup;

[0050] (2) According to the quality score, the SiO will be 2 45％，CaCO 3 25％，Na 2 CO 3 20％，P 2 O 5 5％，MgCO 3 5% fully mixed, calcined at high temperature at 1100 °C, and kept the temperature stable for 6h to form a stable molten state bioactive material;

[0051] (3) The prepared natural biological bone scaffold material is fixed with high-temperature ceramic material, and its vibration is placed in the...

Embodiment 3

[0056] The present embodiment provides a method for preparing an artificial bone repair material, comprising the following steps:

[0057] (1) Take natural pine beef bone, prepare a long strip structure of 1cm*1cm*2cm, remove blood fat and bone marrow and other components and rinse fully, and then use hydrogen peroxide ultrasonically soaked for 90min to further remove fat components, soaked in absolute ethanol for 30min to further inactivate the virus components, and then further cleaned with surfactant in water and dried, to obtain natural biological bone scaffold material backup;

[0058] (2) According to the quality score, the SiO will be 2 45％，CaCO 3 22％，Na 2 CO 3 20％，P 2 O 55％，MgCO 3 8% well mixed, calcined at high temperature at 1100 °C, and kept at a stable temperature for 6h to form a stable molten state bioactive material;

[0059] (3) The prepared natural biological bone scaffold material is fixed with high-temperature ceramic material, and its vibration is placed in the...

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Abstract

The invention belongs to the technical field of biomaterials, and in particular relates to an artificial bone repair material with osteogenic activity, a preparation method and application thereof. The preparation method of the artificial bone repair material with osteogenic activity is to attach the bioactive material to the surface of the skeleton with a three-dimensional structure, and then quench; wherein, the bioactive material is in a molten state, and the skeleton is vibrated. complex. The present invention adopts the attachment method combining "molten form" and "vibration", which can make the bioactive material adhere to the surface of the basic skeleton better and evenly, and the degree of bonding is higher, and the surface structure is more regular, which can significantly improve the Comprehensive properties of artificial bone repair materials.

Description

Technical field [0001] The present invention belongs to the field of biomaterial technology, specifically relates to an artificial bone repair material having osteogenesis activity and mechanical support properties and preparation methods and applications thereof. Background [0002] The ideal artificial bone repair material should have the following characteristics: the primary role is structural support, which must have a certain mechanical strength and toughness; secondly, it should also have good biocompatibility, degradability and bone conductivity; in addition, it should have a suitable pore structure to facilitate cell proliferation and differentiation on its surface. [0003] Biologically derived bone has a natural three-dimensional spatial structure, which is conducive to promoting the growth and adhesion of bone cells, but its disadvantage is that the mechanical properties are poor, generally can only be used as a filling material and can not play a mechanical support p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/12A61L27/02A61L27/50A61L27/54A61L27/56
CPCA61L27/3608A61L27/365A61L27/3687A61L27/3691A61L27/12A61L27/025A61L27/50A61L27/54A61L27/56A61L2430/02A61L2300/412A61L2430/40
Inventor 常丽侯兵兵李得阳
Owner 北京德得创业科技有限公司
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