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Method for extracting related posterior cingutate function connectivity characteristics of type 2 diabetes patient with cognitive impairment

A type 2 diabetes, cognitive impairment technology, applied in the medical field, can solve problems such as unclear relationship

Active Publication Date: 2020-09-29
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Therefore, the alteration of PCC in T2DM patients and its relationship with cognitive impairment is unclear

Method used

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  • Method for extracting related posterior cingutate function connectivity characteristics of type 2 diabetes patient with cognitive impairment
  • Method for extracting related posterior cingutate function connectivity characteristics of type 2 diabetes patient with cognitive impairment
  • Method for extracting related posterior cingutate function connectivity characteristics of type 2 diabetes patient with cognitive impairment

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] Materials and Methods

[0023] Sample personnel

[0024] We recruited 48 participants (24 T2DM patients and 24 healthy controls). Informed consent was obtained from each participant. According to the latest standard published by the American Diabetes Association: HbA 1c ≥6.5% (48mmol / mol); fasting blood glucose ≥7.0mmol / L (126mg / dL); oral glucose tolerance test (OGTT) 2h postprandial blood glucose ≥1.1mmol / L (200mg / dL); hyperglycemia or risk of hyperglycemia Symptoms and random blood glucose ≥ 11.1mmol / L (200mg / dL), no symptoms of hyperglycemia, review 1 to 3 criteria, match the control group with T2DM patients in terms of age, gender and education, MOCA score greater than or equal to 26. Participants were excluded if they had a history of psychiatric illness, stroke, epilepsy, head trauma, brain surgery, cerebrovascular accident, or evidence of impaired cognitive function, or had severe hepatic, renal, or cardiac disease. Alcohol or tobacco abuse, hypertension, and...

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Abstract

The invention discloses a method for extracting related posterior cingutate function connectivity characteristics of a type 2 diabetes patient with cognitive impairment. The method comprises the following specific steps: sample personnel collection, medical history and biological characteristic measurement, cognitive assessment, MRI data collection, small vessel disease assessment, functional dataanalysis, statistical analysis, head movement analysis, functional connection analysis and correlation analysis. According to the invention, the weak FC of the PCC to a plurality of brain regions ismore accurately verified to be related to the cognitive impairment of a T2DM patient; and the FC pathways of the PCC may be used as biomarkers to further reveal a biological mechanism in the potentialneuropathological process of T2DM-related cognitive impairment, and may provide evidence for further molecular biological research.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for extracting features of posterior cingulate functional connectivity related to type 2 diabetic cognitive impairment patients. Background technique [0002] The posterior cingulate cortex (PCC) is considered the cortical hub of the default mode network (DMN). The goals of our current study were to determine whether PCC is associated with altered functional connectivity (FC) across brain regions in type 2 diabetes (T2DM) and to determine their relationship to cognitive impairment. In this study, FC characterization of PCC was performed in 24 patients with T2DM using resting-state functional MRI and a seed-based whole-brain correlation approach, compared with 24 well-matched healthy controls. Spearman's correlation analysis was used to determine the relationship between FC in PCC and cognitive impairment. T2DM was associated with significantly lower FC from the PCC to a broad r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/00G16B40/00G16B50/00
CPCG16B20/00G16B40/00G16B50/00
Inventor 邱士军谭欣覃春红冷西陈羽娜郑燕婷梁馨予刘玉洁李伊凡杨锦泉
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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