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Calculation method for prompting Alzheimer's disease risk of old men by androgen

A technology of Alzheimer's disease and calculation method, which is applied in the field of calculation of androgen prompting the risk of Alzheimer's disease in elderly men. It can solve the problems of complex operation, large invasiveness, and difficulty in large-scale application, and achieve high prediction value effect

Inactive Publication Date: 2020-07-14
HEBEI MEDICAL UNIVERSITY
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  • Description
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Problems solved by technology

However, when clinically diagnosing AD, relying solely on clinical symptoms without the support of biomarkers will reduce the specificity of diagnosis; and although the inclusion of biomarkers increases the specificity of diagnosis, it has been Most of the examinations of biomarkers added to the diagnostic standard are complex, invasive, and expensive, and are not suitable for clinical promotion and are difficult to apply on a large scale

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  • Calculation method for prompting Alzheimer's disease risk of old men by androgen
  • Calculation method for prompting Alzheimer's disease risk of old men by androgen
  • Calculation method for prompting Alzheimer's disease risk of old men by androgen

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Embodiment Construction

[0028] 1 material

[0029] 1.1 Research object

[0030] 1.1.1 Sources of research objects

[0031] From March to July 2018 and March to July 2019, 4 community health service centers were randomly selected in each main urban area of ​​Shijiazhuang City, Hebei Province. Since then, more than 3,000 elderly people over 65 years old have undergone physical examination in the 4 community health service centers. Men were studied and their physical health, mental status and cognitive function were assessed. A total of 2062 people cooperated and completed the cognitive function test, including 1665 people with normal cognition, 290 people with aMCI, and 65 people with AD. 576 of these people received blood collection for the purpose of the experiment, including 243 with normal cognition, 271 with aMCI, and 62 with AD.

[0032] The study was approved by the Ethics Committee of Hebei Medical University, and written informed consent was obtained from each subject.

[0033] 1.1.2 Inclu...

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Abstract

The invention provides a calculation method for prompting the Alzheimer's disease (AD) risk of old men by androgen. The method comprises the following steps: constructing an equation model, fitting anROC curve, and calculating a diagnosis boundary value cutoff value, so as to obtain an androgen laboratory reference value of amnetic mild cognitive impairment (aMCI). The method comprises the following specific steps: referring to a result of single-factor analysis of aMCI and cognitive normality comparison, selecting variables with statistical significance to further perform multi-factor logistic regression analysis to obtain independent prediction factors of aMCI, and constructing an equation; the method has a high prediction value, and can prompt possible aMCI risks.

Description

technical field [0001] The invention relates to a risk calculation method, in particular to a calculation method for androgen prompting the risk of Alzheimer's disease in elderly men. Background technique [0002] The world's first internationally recognized diagnostic criteria for Alzheimer's Disease (AD) was the NINCDS-ADRDA diagnostic criteria published by the National Association of Neurology and Speech Disorders, Stroke and Alzheimer's Disease and Related Diseases in 1984. Over the past 30 years, as people's understanding of AD disease and the ability to detect its pathophysiological process have improved, the concept of the clinical spectrum of the disease has undergone earth-shaking changes. AD diagnostic criteria are also constantly updated and improved, after NINCDS-ADRDA criteria (1984) - IWG criteria (2007, 2010) - NIA-AA criteria (2011) - IWG2 criteria (2014) 4 stage. Whether it is the NIA-AA criteria or the IWG criteria, there is consensus on the concept of AD...

Claims

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Application Information

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IPC IPC(8): G16H50/30G16H50/20G06F17/11G06F17/18
CPCG16H50/30G16H50/20G06F17/11G06F17/18
Inventor 崔慧先李莎李妍刘晓云
Owner HEBEI MEDICAL UNIVERSITY
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