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Bifidobacterium lactis Probio-M8 capable of relieving and improving symptoms of Alzheimer's diseases and applications thereof

A bifidobacterium lactis, symptom technology, applied in the direction of bifidobacteria, medical preparations containing active ingredients, applications, etc., can solve the problem of lack of efficient, safe, non-toxic probiotics for Alzheimer's disease, etc.

Active Publication Date: 2020-05-19
BEIJING SCITOP BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the different probiotic effects of probiotic strains, there is currently a lack of probiotics that are highly effective, safe, non-toxic and effective in alleviating Alzheimer's disease

Method used

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  • Bifidobacterium lactis Probio-M8 capable of relieving and improving symptoms of Alzheimer's diseases and applications thereof
  • Bifidobacterium lactis Probio-M8 capable of relieving and improving symptoms of Alzheimer's diseases and applications thereof
  • Bifidobacterium lactis Probio-M8 capable of relieving and improving symptoms of Alzheimer's diseases and applications thereof

Examples

Experimental program
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Effect test

experiment example

[0041] Experimental example: Application analysis of Bifidobacterium lactis Probio-M8 in the clinical efficacy observation test of mice

[0042] Experimental method: Taking Bifidobacterium lactis Probio-M8 (Bifidobacterium lactis Probio-M8) as the research object, a 2-month-old male mouse transgenic for APP / PS1 was selected to spontaneously pair with 3 wild-type female mice of the same age to produce . After 30 days, 18 fetal mice were born, and all fetal mice were genotyped to obtain the number of APP / PS1 mice and wild-type mice. After the mice were fed normally until they were 4 months old, 7 mice with the genotype of APP / PS1 were randomly divided into two groups, one group was given Bifidobacterium lactis Probio-M8 (4 mice), and the other group was given Normal saline (3 rats), the duration of gavage continued for 45 days. After 45 days, the mice were sacrificed, and the brain tissues of the mice were taken out. After being fixed in 4% paraformaldehyde at 4°C for 24 hou...

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Abstract

The invention discloses bifidobacterium lactis Probio-M8 capable of relieving and improving symptoms of Alzheimer's diseases and applications thereof. APP / PS1 mice are taken as experimental subjects;7 mice whose genotypes are APP / PS1 are selected from the mice delivered through paired reproduction with wild mice; and after the random dividing of the mice into two groups, the bifidobacterium lactis Probio-M8 is poured into the stomach of the mice in one group, and normal saline is poured into the stomach of the mice in the other group, so that the changing of the number of A[beta] plaques in the brains of the mice can be determined. Through the proving of experimental results, the bifidobacterium lactis Probio-M8 has the effects of relieving and improving the symptoms of Alzheimer's diseases.

Description

technical field [0001] The application relates to the field of biotechnology, in particular to a bifidobacterium lactis capable of relieving and improving Alzheimer's symptoms and its application. Background technique [0002] With the increase of average life expectancy in my country and the approaching of an aging society, an ancient disease that seriously threatens the health of the elderly and even the development of society - Alzheimer's disease (Alzheimer's disease, AD), also known as senile Dementia, a degenerative disease of the central nervous system, has begun to appear on a large scale among the elderly population in my country. Clinically, it is mainly manifested as neuropsychiatric symptoms such as progressive memory impairment, cognitive dysfunction, personality changes, and language barriers, which seriously affect social, occupational, and life functions. Unlike other senile diseases, the cause of Alzheimer's disease is unknown so far, and there is no effecti...

Claims

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Application Information

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IPC IPC(8): C12N1/20A61K35/745A61P25/28A23L33/135A23K10/18A23C9/123C12R1/01
CPCC12N1/20A61K35/745A61P25/28A23L33/135A23K10/18A23C9/1234A23V2002/00C12R2001/01C12N1/205A23V2400/531A23V2200/322
Inventor 刘晓军其木格苏都宋继宏马杰张建军张凌宇姚国强
Owner BEIJING SCITOP BIO TECH CO LTD
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