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Composition containing alpinia oxyphylla extract as active ingredient for prevention, alleviation, or treatment of osteoarthritis

A technology for osteoarthritis and active ingredients, applied in the field of composition and prevention for improving or treating osteoarthritis, and can solve the problems of osteoarthritis and other problems that are not disclosed by nootropic extracts

Inactive Publication Date: 2020-05-01
KOREA INST OF ORIENTAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, Korean Laid-Open Patent No. 2012-0109140 discloses a composition for treating lung cancer and a health food containing the extracts of japonica japonicus. Radix Paeoniae Alba extract and the pharmaceutical composition containing it, but the composition for preventing, improving or treating osteoarthritis containing nootropic extract as an active ingredient as in the present invention has not been disclosed

Method used

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  • Composition containing alpinia oxyphylla extract as active ingredient for prevention, alleviation, or treatment of osteoarthritis
  • Composition containing alpinia oxyphylla extract as active ingredient for prevention, alleviation, or treatment of osteoarthritis
  • Composition containing alpinia oxyphylla extract as active ingredient for prevention, alleviation, or treatment of osteoarthritis

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Example 1. Preparation of Yizhiren extract

[0032] Add 15 liters of 70% (v / v) ethanol to 1 kg of Yizhiren, and perform reflux extraction at 85°C for 3 hours. The filtrate is concentrated under reduced pressure at 50°C, and 11.7 is obtained after drying. g's nootropic extract.

Embodiment 2

[0033] Example 2. Confirmation of the effect of extracts of alpinia on body weight in an animal model of osteoarthritis induced by MIA (monosodium iodoacetate)

[0034] In order to confirm the effect of the extract prepared in Example 1 on the body weight load in an animal model of osteoarthritis induced by MIA, the MIA (using 0.9% physiological Saline (saline) diluted to a concentration of 60mg / ml) was administered into the articular cavity of the right hind leg of 7-week-old SD rats to induce osteoarthritis, and then once a day orally administered Yizhiren extract The body weight load rate was measured for 21 days (150 mg / kg and 300 mg / kg), 7 days apart. Indomethacin (1mg / kg) was used as a positive control group.

[0035] The body weight load rate of the hind legs was measured using a bipedal balance pain tester (Incapacitance tester, Lintoninstrument Co., UK, Ser No. 01 / 45 / 25). In the fixture of the pain tester, the rats with induced osteoarthritis stand on the normal legs wit...

Embodiment 3

[0039] Example 3. Confirmation of the effect of nootropic extract on inflammation-inducing factors and cartilage degeneration-inducing factors in an animal model of osteoarthritis induced by MIA (monosodium iodoacetate)

[0040] MRNA was extracted from the joints that induced osteoarthritis, and the inflammation-inducing factors (interleukin 1β, interleukin 6, tumor necrosis factor α and cyclooxygenase 2) and cartilage degeneration inducing factors (matrix metalloproteinase 2) were confirmed by PCR. 9) Expression.

[0041] The result is figure 2 As shown, it was confirmed that the expression of inflammation-inducing factors and cartilage degeneration-inducing factors were increased in the samples of osteoarthritis induced by MIA. On the contrary, the expression of the increased factors was increased when the extracts of almonds were used in parallel. decreased. Therefore, it can be seen that the extract of nootropics can inhibit the inflammation induced by osteoarthritis and the ...

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Abstract

The present invention relates to a composition containing an Alpinia oxyphylla extract as an active ingredient for prevention, alleviation, or treatment of osteoarthritis. Specifically, an Alpinia oxyphylla Fructus extract of the present invention reduces the expression of IL-1beta, IL-6, TNF-alpha, and COX-2, which are inflammation factors, also reduces the expression of MMP-9, which is a cartilage degeneration inducing factor, and restores cartilage injury, and thus can be favorably used as a health functional food for prevention or alleviation of osteoarthritis or a therapeutic agent for osteoarthritis.

Description

Technical field [0001] The present invention relates to a composition for preventing, improving or treating osteoarthritis containing nootropic extract as an effective ingredient. Background technique [0002] Arthritis is a disease caused by inflammation and pain in the joints, including osteoarthristis, rheumatoid arthritis, gout, and dry arthritis. 95% of arthritis patients suffer from osteoarthritis . Osteoarthritis is a disease that shows local degenerative changes as articular cartilage wears out, and is also called degenerative arthritis. Osteoarthritis is a typical degenerative disease related to aging. The disease rate accounts for about 10-15% of the total population, especially among the elderly over 65 years old, about 60-80% suffer from osteoarthritis. [0003] The etiology of osteoarthritis is deeply related to aging or excessive weight. As we age, more women suffer from more severe symptoms. The initial symptoms are ankylosis and pain in one or two joints. As the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A61K36/906
CPCA23L33/105A23V2002/00A23V2200/306A61P19/02A61K36/9062A61K2236/333A61K9/0095A61K9/0053A61K36/906
Inventor 金东善李允美孙银贞金志妍
Owner KOREA INST OF ORIENTAL MEDICINE
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