A plant polyphenol-polyacryloylmorpholine composite modified hemodialysis membrane and its preparation method and application

Abstract

The invention proposes a plant polyphenol-polyacryloylmorpholine composite modified hemodialysis membrane and its preparation method and application, and relates to the technical field of modified hemodialysis membranes. The method comprises the following steps: 1) preparing a mixed solution of plant polyphenols; 2) preparing a mixed solution of polyacryloylmorpholine; 3) flowing the mixed solution of plant polyphenols through a hemodialysis membrane at a constant temperature to obtain a modified plant polyphenol Hemodialysis membrane; 4) At a constant temperature, the above-mentioned polyacryloylmorpholine mixed solution flows through the above-mentioned plant polyphenol modified hemodialysis membrane to obtain a plant polyphenol-polyacryloylmorpholine composite modified hemodialysis membrane. The plant polyphenol-polyacryloylmorpholine composite modified hemodialysis membrane proposed in the embodiment of the present invention is mainly used for hemodialysis, has good biocompatibility, and realizes the purpose of the hemodialysis membrane intervening in oxidative stress.

Description

technical field [0001] The invention belongs to the technical field of modified hemodialysis membranes, and in particular relates to a plant polyphenol-polyacryloylmorpholine composite modified hemodialysis membrane and its preparation method and application. Background technique [0002] In recent years, the number of patients with end-stage renal disease has been increasing. Due to renal insufficiency or even complete loss in such patients, hemodialysis has become the main measure to replace the kidney. However, the hemodialysis membrane is the core material of hemodialysis. Due to the biocompatibility of the dialysis membrane, it is easy to cause the adhesion and activation of leukocytes in the patient's blood, and a large number of reactive oxygen species (ROS) are generated during the dialysis process. ), excessive active oxygen free radicals lead to the disorder of its balance with antioxidant substances, resulting in oxidative stress; and, excessive active oxygen free...

AI Technical Summary

Problems solved by technology

However, the hemodialysis membrane is the core material of hemodialysis. Due to the biocompatibility of the dialysis membrane, it is easy to cause the adhesion and activation of leukocytes in the patient's blood, and a large number of reactive oxygen species (ROS) are generated during the dialysis process. ), excessive active oxygen free radicals lead to the disorder of its balance with antioxidant substances, resulting in oxidative stress; and, excessive active oxygen free radicals will react with biomolecules including lipids, polypeptides, nucleic acids, etc., causing lipid peroxidation , protein denaturation, vascular damage, etc., further aggravating oxidative stress

[0003] A large number of studies have confirmed that oxidative stress can easily induce complications such as cardiovascular disease, diabetes, malignant tumors, and neurodegenerative diseases in dialysis patients, which seriously affects the prognosis and long-term survival rate of dialysis patients

At present, the existing hemodialysis membranes on the market cannot improve the state of oxidative stress. Therefore, research and development of a functional hemodialysis membrane, while maintaining good biocompatibility, can prevent oxidative stress damage during hemodialysis. effective intervention is necessary

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