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Method for detecting adverse reaction signals of combined medication

A technology of adverse reactions and drug combination, applied in the direction of drug reference, etc., can solve the problems of difficulty and limitation in obtaining drug-protein interaction data

Pending Publication Date: 2020-02-07
NANJING UNIV OF POSTS & TELECOMM
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Problems solved by technology

However, these methods have difficulties and limitations in obtaining drug molecular structure and drug-protein interaction data

Method used

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  • Method for detecting adverse reaction signals of combined medication
  • Method for detecting adverse reaction signals of combined medication
  • Method for detecting adverse reaction signals of combined medication

Examples

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Embodiment Construction

[0044] The present invention discloses a method for detecting signals of adverse reactions of drug combination, comprising the following steps:

[0045] S1. Raw data acquisition and processing steps:

[0046] Step 1.1) Data acquisition: There are 1,823,144 ADR reports in the National Adverse Drug Reaction Testing Center from January 1, 2010 to December 31, 2011, including 879,109 single drug reports and 330,235 combined drug reports. Using Microsoft Visual FoxPro software to select 183 kinds of antipsychotic and antiepileptic drugs, of which 1,707 records of combined drug data include 1,159 combined drug combinations, and 1,698 single drug data records include 36 drugs and 393 adverse reactions. Accounting for 50.13% of the total data. In this example, western medicine data is selected as the experimental object.

[0047] Step 1.2) Data processing: re-normalize the inconsistent data between the drug name and the adverse reaction name in the single drug and combined drug data...

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Abstract

The invention discloses a method for detecting adverse reaction signals of combined medication. The method comprises steps of S1 of data acquisition and processing, acquiring ADR original data and performing data processing; S2 of acquisition and standardization of known data of untoward effects of combined medication, and obtaining data as a contrast database of a result evaluation standard through a public searchable database; S3 of integration of new drugs of combined medication, processing two drugs in the data with the same report code in a combined medication report into a new drug in anA+B format; S4 of generation of a new data set, combining individual medication data with the new drug data for combined medication; S5 of signal detection, carrying out data mining and analysis by utilizing an MHRA+ algorithm; S6 of detection signal evaluation, extracting a signal expressed as A+B->ADR in an output result, comparing the signal with a known database, and evaluating effectivenessof the result. The method is advantaged in that combined medication is regarded as new drug combined report data to serve as a combined medication data set, so correlation between medicines of the combined medication and the adverse reaction can be effectively measured, and the method is used for detecting an adverse reaction signal of the combined medication.

Description

technical field [0001] The invention relates to a method for detecting adverse reaction signals of drug combination, which belongs to the field of drug safety data mining. Background technique [0002] With the increasing number of new drugs and the increasing prescriptions of combined drugs, many potential adverse reactions induced by drug interactions continue to appear, which not only bring additional burdens to patients, but even threaten the lives of patients in severe cases. According to the statistics of the US Food and Drug Administration (FDA), the proportion of adverse reactions caused by drug interactions is between 6% and 30%, affecting 50% of hospitalized patients. [0003] Regarding the mining and analysis of adverse drug reaction signals of combination drugs, there is currently no unified international standard, and the analysis of Adverse Drug Reaction (ADR) of combination drugs is still a hot topic in current research. Monitoring the safety of drug combinat...

Claims

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Application Information

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IPC IPC(8): G16H70/40
CPCG16H70/40
Inventor 魏建香张亚楠刘天宇卢志强
Owner NANJING UNIV OF POSTS & TELECOMM
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