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Hepatocellular carcinoma alternative splicing event prognosis model and construction method and application thereof

A technology for hepatocellular carcinoma and a construction method, which is applied to the prognostic model of alternative splicing events in hepatocellular carcinoma and the field of its construction, which can solve the problems of complex phenotypes of proteomic diseases and the like

Pending Publication Date: 2019-10-29
段艺
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Problems solved by technology

Essentially, pre-mRNAs can be spliced ​​into different permutations to produce structurally and functionally distinct protein variants by removing intronic regions and selectively incorporating or excluding specific exons within genes containing multiple exons. body, which further contributes to proteome diversity and contributes to the complexity of disease phenotypes

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  • Hepatocellular carcinoma alternative splicing event prognosis model and construction method and application thereof
  • Hepatocellular carcinoma alternative splicing event prognosis model and construction method and application thereof
  • Hepatocellular carcinoma alternative splicing event prognosis model and construction method and application thereof

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Embodiment Construction

[0029] In order to facilitate the understanding of the present invention, the present invention will be described in more detail below in conjunction with the accompanying drawings and specific embodiments. Unless otherwise defined, all technical and scientific terms used in this specification have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terms used in the description of the present invention in this specification are only for the purpose of describing specific embodiments, and are not used to limit the present invention. The term "and / or" used in this specification includes any and all combinations of one or more of the associated listed items. The present invention can use any method known in the art to measure the expression of the 26 alternative splicing events contained in the constructed model. Those skilled in the art should understand that the means of measuring event expression is not an important as...

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Abstract

The invention relates to a hepatocellular carcinoma alternative splicing event prognosis model and a construction method and an application thereof. The prognosis alternative splicing variation of patients with hepatocellular carcinoma is systematically evaluated, a hepatocellular carcinoma alternative splicing prognosis model based on 26 alternative splicing events is constructed, the independentprognostic ability is verified further in combination with clinical pathological variables, and the key alternative splicing events related to the overall survival of the patients with hepatocellularcarcinoma are obtained. The research results show that the candidate events included in the final alternative splicing prognosis model are related to regulation of hepatocellular carcinoma, and the related key events can serve as potential biomarkers or therapeutic targets of hepatocellular carcinoma and are of clinical significance for deciphering the potential mechanism of hepatocellular carcinoma in tumor formation and pathogenesis.

Description

technical field [0001] The present invention relates to the field of hepatocellular carcinoma, in particular to a prognostic model of alternative splicing events of hepatocellular carcinoma and its construction method and application. Background technique [0002] Hepatocellular carcinoma (HCC) is one of the main causes of high cancer morbidity and mortality worldwide. According to statistics, about one million people die from HCC every year. In addition, the recurrence rate of hepatocellular carcinoma is very high. Even for patients who have received early hepatocellular carcinoma resection, the 5-year survival rate is only nearly 30%. Due to the heterogeneity and complexity of HCC, traditional clinicopathological and molecular markers are difficult to comprehensively identify the carcinogenesis, progression, invasion, and metastasis characteristics of HCC. At present, the risk assessment, treatment decision, and prognosis prediction of HCC mainly rely on the traditional T...

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Application Information

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IPC IPC(8): G16B20/00G16B40/00G16H50/20G16H50/50
CPCG16B20/00G16B40/00G16H50/20G16H50/50
Inventor 张东段艺
Owner 段艺
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