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A composition for improving ovarian reserve function and preventing premature ovarian failure and its application

A technology for ovarian reserve and hypofunction, applied in application, drug combination, function of food ingredients, etc., can solve problems such as low ovarian reserve function

Active Publication Date: 2021-02-26
北京华睿鼎信科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the current clinical practice, DHEA is used alone to treat women with low ovarian reserve function. There is no public report that DHEA combined with levocarnitine has stronger efficacy and more definite curative effect in the treatment of ovarian reserve decline. Therefore, the present invention is an improvement on the existing A major improvement breakthrough in technology

Method used

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  • A composition for improving ovarian reserve function and preventing premature ovarian failure and its application
  • A composition for improving ovarian reserve function and preventing premature ovarian failure and its application
  • A composition for improving ovarian reserve function and preventing premature ovarian failure and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 dehydroepiandrosterone and levocarnitine composition hard capsule (10000 prescriptions)

[0027]

[0028]

[0029] Weigh the raw materials of the prescription amount, pass through an 80-mesh sieve for subsequent use, and the auxiliary materials pass through a 60-mesh sieve for subsequent use. Prepare 80% ethanol solution for later use. Thoroughly mix DHEA, levocarnitine, magnesium oxide, starch, sodium starch glycolate and sodium lauryl sulfate evenly. The mixed powder is made into a soft material with the above-mentioned 80% ethanol solution, and granulated through a 16-mesh sieve. The prepared wet granules are dried at 50°C to 60°C. The dry granules are sized with a 16-mesh sieve. Add the prescribed amount of magnesium stearate to the granulated granules and mix well. Fill capsules, each containing 25mg of DHEA and 200mg of L-carnitine.

Embodiment 2

[0030] The preparation of embodiment 2 dehydroepiandrosterone and acetyl-levocarnitine soft capsules (10000 prescriptions)

[0031]

[0032] Weigh the prescribed amount of dehydroepiandrosterone and acetyl-levocarnitine and add them to the corn oil and stir evenly. Take a specified amount of succinylated gelatin, gelatin, glycerin, and D-sorbitol, disperse them in an appropriate amount of purified water, stir at 60°C to dissolve, and prepare soft capsules by using a soft capsule forming machine punching method. The content of each capsule contains dehydrogenated form Androsterone 20mg, acetyl L-carnitine (calculated as L-carnitine) 150mg.

Embodiment 3

[0033] The preparation of embodiment 3 dehydroepiandrosterone sulfate and levocarnitine tablet (10000 prescriptions)

[0034]

[0035] Weigh the raw and auxiliary materials of the prescription amount, the raw materials are passed through an 80 mesh sieve, and the microcrystalline cellulose and cross-linked sodium carboxymethyl cellulose are passed through a 60 mesh sieve for subsequent use. Add dehydroepiandrosterone sulfate, levocarnitine, croscarmellose sodium, and microcrystalline cellulose into the tank mixer, and mix for 20 minutes. After fully mixing the aforementioned raw and auxiliary materials, add purified water, mix for 10 minutes, pass through a 16-mesh sieve to granulate, and dry the prepared wet granules at 40-50°C. The dry granules are sized with a 16-mesh sieve. Add the prescribed amount of magnesium stearate and silicon dioxide to the granulated granules, and mix well. Regulate tablet press and carry out tabletting, each tablet contains dehydroepiandroste...

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PUM

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Abstract

The present invention describes a synergistic composition and its use in the preparation of a medicament or a dietary supplement for improving diminished ovarian reserve (DOR) and preventing premature ovarian failure in women. The composition comprises dehydroepiandrosterone (DHEA) or dehydroepiandrosterone sulfate (DHEAS) and levocarnitine or acetyl levocarnitine or a pharmaceutically acceptable salt thereof, which is safer and more effective than the prior art , showed a better effect than administration of DHEA or DHEA sulfate alone.

Description

technical field [0001] The invention relates to a composition for improving female ovarian reserve function and preventing premature ovarian failure and its application, in particular to a composition comprising dehydroepiandrosterone (DHEA) or dehydroepiandrosterone sulfate (DHEAS) and levocarnitine or A composition of acetyl-levocarnitine or a pharmaceutically acceptable salt thereof and its application in improving women's decreased ovarian reserve and preventing premature ovarian failure. Background technique [0002] The age of modern women's willingness to bear children is increasingly delayed, as well as people's living environment and social pressure factors, and the phenomenon of female infertility is also becoming more and more serious. Studies have shown that as women age, their ovarian reserve function decreases, and they are prone to premature ovarian failure, which in turn leads to reduced fertility. The clinical practice guidelines of the American College of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5685A61K31/205A61P15/08A23L33/10
CPCA23V2002/00A61K31/205A61K31/5685A23L33/10A61P15/08A61K2300/00A23V2200/30
Inventor 常珍张婵娟况斌吕宁
Owner 北京华睿鼎信科技有限公司
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