Accessory materials for delivery to colonic tissue

Abstract

The present invention provides adjunct materials for delivery to colon tissue. Generally, the appendage material can be configured to be delivered to colonic tissue by staple deployment from a cartridge body of a surgical stapler to form at least one deployed staple thread. The appendage material may be formed from a fibrous matrix and include an effective amount of one or more agents for delivery to the colonic tissue. The agent is disposed within and releasable from the appendage material and is effective to promote a desired effect on the blood vessel, such as angiogenesis and / or vasodilation, along the at least one deployed staple line. Also provided are methods of applying such adjunct materials to colonic tissue using a cartridge assembly or an end effector.

Description

Technical field[0001]The present disclosure generally relates to accessory materials for delivery to colonic tissue.Background technique[0002]Surgical staplers are used in surgical operations to close openings in tissues, blood vessels, catheters, shunts, or other objects or body parts involved in a particular operation. These openings may be naturally occurring, such as passages in blood vessels or internal organs similar to the stomach, or they may be formed by the surgeon during surgery, such as by puncturing tissue or blood vessels to form a bypass or anastomosis or passing through Cut tissue during suture surgery.[0003]Most staplers have a handle with an elongated shaft with a pair of movable opposed jaws formed on its ends for holding nails between the jaws and making Nail forming. The staples are usually housed in a staple cartridge that can hold multiple rows of staples and is usually provided in one of the two jaws for ejecting the staples to the surgical site. During use, ...

AI Technical Summary

Problems solved by technology

However, the use of biomaterials presents several additional problems

For example, it may be difficult to maintain the position of the biological material relative to the jaws of the staples before and during staple ejection

It can also be difficult to keep the biomaterial in the desired position at the surgical site after sutures are completed

Additionally, it can be difficult to fabricate biomaterials into the desired shape and thickness

Commonly used plastic and molding manufacturing techniques are often not conducive to fabricating thin biolayers for use with surgical staplers

The fragile nature of many biomaterials also makes them difficult to use in surgical staplers because they lack structural support

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