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A traditional Chinese medicine composition with whitening function, preparation method and application

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition with whitening function and preparation thereof, can solve the problems of large side effects, easy decomposition, skin pigmentation and the like, and achieve the effects of stable properties, promotion of metabolism and less skin irritation

Active Publication Date: 2020-05-15
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, hydroquinone is banned due to excessive side effects, kojic acid and its derivatives have strong whitening effect, but they are easy to decompose when exposed to light and heat, whitening preparations containing chemical ingredients or heavy metals are likely to cause skin pigmentation after use, and have relatively large side effects

Method used

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  • A traditional Chinese medicine composition with whitening function, preparation method and application
  • A traditional Chinese medicine composition with whitening function, preparation method and application
  • A traditional Chinese medicine composition with whitening function, preparation method and application

Examples

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preparation example Construction

[0076] Preparation of reference substance solution: Accurately weigh 80.04mg L-ascorbic acid and 48.10mg citric acid and respectively settle in a 50mL volumetric flask to obtain 1.601mg / mL L-ascorbic acid standard solution and 0.962mg / mL citric acid reference substance solution , and then take 2.5mL of citric acid reference solution and 0.4mL of L-ascorbic acid standard solution in a 5mL volumetric flask, add water to dilute to the mark, and shake well to obtain 0.481mg / mL of citric acid reference solution and 0.128mg / mL - Ascorbic acid standard solution. For the chromatogram of the reference substance, see figure 2 .

[0077] The preparation of need testing solution: the traditional Chinese medicine composition that the orthogonal test constant volume gets 4mL and is settled to 10mL volumetric flask, crosses the microporous membrane of 0.45 μ l, promptly as need testing solution. For the chromatogram of the test product, see image 3 .

[0078] Linear relationship invest...

Embodiment 4

[0115] Take 20g of ebony plum, 5g of hawthorn, and 25g of raspberry, a traditional Chinese medicine for nourishing the liver and kidney, and put them into a beaker, add 14 times the total weight of each component, soak in water for 0.5h, heat and decoct twice, 1.5 hours each time. The decoction liquids obtained from the two decoctions were suction-filtered respectively, and the filtrates were combined, and the above-mentioned filtrates were concentrated at 80° C. to a crude drug content of 0.22 g / mL to obtain the traditional Chinese medicine composition.

Embodiment 5

[0117] Take 20g of ebony plum, 5g of hawthorn, 25g of raspberry and 5g of mulberry in a beaker, add 14 times the total weight of each component to soak in 90% ethanol for 0.5h, heat and decoct twice, 1.5 hours each time. The decoction liquids obtained from the two decoctions were suction-filtered respectively, and the filtrates were combined, and the above-mentioned filtrates were concentrated at 80° C. to a crude drug content of 0.22 g / mL to obtain the traditional Chinese medicine composition.

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Abstract

The invention discloses a traditional Chinese medicine composition with a whitening function. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-30 parts of fructus mume, 5-25 parts of fructus crataegi and 5-50 parts of traditional Chinese medicines for nourishing liver and kidney. According to the traditional Chinese medicine composition, the traditional Chinese medicine components are screened by the theory of treatment based on syndrome differentiation according to the traditional Chinese medicine theory; the traditional Chinese medicine composition is scientific and reasonable in ratio, has a good effect on inhibiting tyrosinase, and is capable of effectively inhibiting melanogenesis and reliving hyperpigmentation, age spots and freckles. Compared with the whitening agent of the prior art, the traditional Chinese medicine composition has a good effect on inhibiting the tyrosinase and has an excellent whitening effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition with whitening function, its preparation method and its application. Background technique [0002] Hyperpigmentation of the skin is closely related to the synthesis of melanin, a biopolymer that is mainly divided into two categories: eumelanin and pheomelanin. The synthesis of melanin mainly occurs in melanosomes, with tyrosine as a substrate, and under the catalysis of tyrosinase, L-Dopa is formed, and L-Dopa is further oxidized to generate dopaquinone (DQ), and then undergoes different The downstream pathway synthesizes eumelanin and brown pigment respectively, and the two are mixed to form melanin. There are three enzymes involved in this process: tyrosinase, dihydroxyindole carboxylic acid (DHICA) oxidase and polychrome isomerase, among which tyrosinase is the main rate-limiting enzyme of melanin synthesis. Studies have...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/9749A61Q19/02A61K36/815A61K36/804A61K36/79A61K36/744A61K36/736A61P17/00
CPCA61K8/97A61K36/11A61K36/185A61K36/21A61K36/254A61K36/28A61K36/355A61K36/39A61K36/40A61K36/43A61K36/46A61K36/481A61K36/536A61K36/57A61K36/60A61K36/605A61K36/638A61K36/704A61K36/73A61K36/734A61K36/736A61K36/744A61K36/79A61K36/804A61K36/815A61K2236/331A61K2236/51A61K2800/782A61Q19/02A61K2300/00
Inventor 张理平王英豪
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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