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Application of Cordyceps sinensis in the preparation of drugs for preventing and/or treating pancreatic fibrosis

A technology of pancreatic fibrosis and Cordyceps sinensis, applied in the field of medicine, to achieve the effect of huge social benefits and research value

Active Publication Date: 2020-07-21
青海珠峰冬虫夏草工程技术研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no literature has reported that it has the effect of preventing and treating pancreatic fibrosis

Method used

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  • Application of Cordyceps sinensis in the preparation of drugs for preventing and/or treating pancreatic fibrosis
  • Application of Cordyceps sinensis in the preparation of drugs for preventing and/or treating pancreatic fibrosis
  • Application of Cordyceps sinensis in the preparation of drugs for preventing and/or treating pancreatic fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The mycelium of Cordyceps sinesis strain Hirsutela sinensis is cultured by liquid fermentation, and then dried and crushed to obtain the cordyceps fermented mycelium powder for use.

Embodiment 2

[0020] Natural Cordyceps sinensis is dried and superfinely pulverized to obtain extremely fine powder of Cordyceps sinensis for use.

Embodiment 3

[0022] The animals were selected as Wistar rats, males, weighing 180-200g, and were divided into control group, model group, and administration group (high, medium, low).

[0023] The powder prepared in Example 1-2 was prepared into a suspension of three doses using 0.5% sodium carboxymethyl cellulose solution as a solvent: 0.75g / (kg·d), 1.5g / (kg·d), 3.0 g / (kg·d), pre-warm at 37℃ for later use.

[0024] Modeling method: The model group and the administration group adopt the method of injecting 2% TNBS into the pancreaticobiliary duct to prepare the model of chronic pancreatitis; the blank control group is a normal rat.

[0025] Grouping and administration method: rats were randomly divided into model groups, the powder of Example 1-2 was 0.75g / (kg·d), 1.5g / (kg·d), 3.0g / (kg·d) three doses Group, another blank control group. After modeling, rats in the administration group began to gavage different concentrations of Cordyceps powder suspension (0.75g / (kg·d), 1.5g / (kg·d), 3.0g / (kg) on...

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Abstract

The invention relates to the medical use of caterpillar fungus and provides application of caterpillar fungus to preparation of the medicine for preventing and / or treating pancreatic fibrosis. The medicine comprises caterpillar fungus used as an active component and one or more medical auxiliary materials; the caterpillar fungus is selected from natural caterpillar fungus, caterpillar fungus fermentation mycelia and an extract of natural caterpillar fungus and caterpillar fungus fermentation mycelia; the extract is selected from one or combination of a water extract, an alcohol extract, an ester extract, an ether extract and a chloroform extract. Through experiments, the influence of caterpillar fungus on rat pancreatic fibrosis is observed; the experiment shows that the caterpillar fungus has an effect of resisting pancreatic fibrosis; therefore, the caterpillar fungus can be used as the active component for preparing the medicine for resisting pancreatic fibrosis and is high in social benefit and research value.

Description

Technical field [0001] The invention belongs to the field of medicine, and relates to the pharmaceutical use of Cordyceps sinensis, in particular to its application in the preparation of drugs for preventing and / or treating pancreatic fibrosis. Background technique [0002] The incidence of chronic pancreatitis has been increasing in recent years. The main pathological change is pancreatic fibrosis. Pancreatic fibrosis is mainly caused by increased synthesis and deposition of extracellular matrix (ECM), which is mainly collagen, in pancreatic tissues, decreased degradation, and loss of dynamic balance between the two. This deposition is not only caused by the increase in ECM synthesis, but to a greater extent by the decrease in degradation. Among them, the activation of pancreatic stellate cell (PSC) is recognized as the initiating link of pancreatic fibrosis. The necrosis repair process of acinar cells after pancreatic injury can lead to the activation, proliferation and secret...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/068A61P1/18
CPCA61K36/068
Inventor 王玉花王辉巩俐英薛霞科巴得霞刘芙蓉
Owner 青海珠峰冬虫夏草工程技术研究有限公司
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