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Nano silicon dioxide grafted organic functional polymer macrolide insecticide sustained-release agent and preparation method thereof

A nano-silicon dioxide and macrolide technology, which is applied in the field of new pesticide formulations, can solve the problems of lack of controlled release ability of active ingredients, poor dispersibility, and difficulty in exerting drug efficacy, so as to improve the utilization rate of pesticides, Low cost and the effect of reducing the number of applications

Active Publication Date: 2019-02-05
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These dosage forms have limitations such as the use of a large number of organic solvents, dust drift, and poor dispersion, and do not have the ability to control the release of active ingredients, resulting in rapid hydrolysis, photolysis or microbial metabolism of pesticides in the target body or in the environment near the target, making them When the concentration drops below the effective concentration, it is difficult to exert the drug effect

Method used

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  • Nano silicon dioxide grafted organic functional polymer macrolide insecticide sustained-release agent and preparation method thereof
  • Nano silicon dioxide grafted organic functional polymer macrolide insecticide sustained-release agent and preparation method thereof
  • Nano silicon dioxide grafted organic functional polymer macrolide insecticide sustained-release agent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] (1) Add 1.0g nano-calcium carbonate, 0.5g cetyltrimethylammonium bromide (CTAB) and 104mL ethanol to a 250mL flask, add 13mL 27wt% ammonia water after ultrasonic dispersion for half an hour, start stirring, and control the reaction temperature in a water bath At 50°C, add 0.02mol ethyl orthosilicate to the above reaction system, and react for 72h;

[0040] (2) adding excessive dilute hydrochloric acid, removing the nano-calcium carbonate template, centrifuging to remove the supernatant and washing the obtained solid, repeating three times, to obtain hollow nano-silica A;

[0041] (3) Add 100mL of water and ethanol (V / V=1:1) and A obtained in step (2) to the three-necked flask, ultrasonically disperse for half an hour and control the reaction temperature at 70°C, add dropwise 0.01mol (CH 3 CH 2 O) 2 CH 3 Si(CH 2 ) 3 NH 2 , reacted for 2 hours, centrifuged to remove the supernatant and washed the obtained solid, and repeated three times to obtain amino-modified holl...

Embodiment 2

[0049] (1) Add 1.5g nano-calcium carbonate, 2.0g cetyltrimethylammonium bromide (CTAB) and 99mL ethanol to a 250mL flask, add 16.5mL 27wt% ammonia water after ultrasonic dispersion for half an hour, start stirring, and control the reaction in a water bath At a temperature of 40°C, add 0.02mol ethyl orthosilicate to the above reaction system, and react for 36 hours;

[0050] (2) adding excessive dilute hydrochloric acid, removing the nano-calcium carbonate template, centrifuging to remove the supernatant and washing the obtained solid, repeating three times, to obtain hollow nano-silica A;

[0051] (3) Add 100mL of water and ethanol (V / V=1:1), A obtained in step (2) to the three-necked flask, ultrasonically disperse for half an hour and control the reaction temperature at 40°C, add dropwise 0.04mol (CH 3 O) 3 Si(CH 2 ) 3 NH 2 , reacted for 2 hours, centrifuged to remove the supernatant and washed the obtained solid, and repeated three times to obtain amino-modified hollow n...

Embodiment 3

[0057] (1) Add 1.5g nano-calcium carbonate, 0.05g cetyltrimethylammonium bromide (CTAB) and 94mL ethanol to a 250mL flask, add 23.5mL 27wt% ammonia water after ultrasonic dispersion for half an hour, start stirring, and control the reaction in a water bath At a temperature of 25°C, add 0.02mol ethyl orthosilicate to the above reaction system, and react for 72 hours;

[0058] (2) adding excessive dilute hydrochloric acid, removing the nano-calcium carbonate template, centrifuging to remove the supernatant and washing the obtained solid, repeating three times, to obtain hollow nano-silica A;

[0059] (3) Add 100mL of water and ethanol (V / V=1:1), A obtained in step (2) to the three-necked flask, ultrasonically disperse for half an hour and control the reaction temperature at 50°C, add dropwise 0.03mol (CH 3 CH 2 O) 2 CH 3 Si(CH 2 ) 3 NH 2 , reacted for 2 hours, centrifuged to remove the supernatant and washed the obtained solid, and repeated three times to obtain amino-modi...

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Abstract

The application relates to a nano silicon dioxide grafted organic functional polymer macrolide insecticide slow-release agent and a preparation method thereof, and limits the insecticide as one of or any combination of more of abamectin and spinetoram. The preparation method comprises: firstly, preparing hollow nano silicon dioxide A, then preparing amino modified hollow nano silicon dioxide B from the hollow nano silicon dioxide A together with an amino silane coupling agent, then preparing C from the amino modified hollow nano silicon dioxide B together with water, an unsaturated monomer compound, an initiator, a catalyst and a surfactant, and preparing an insecticide nano slow-release agent from C together with an insecticide. The preparation method provided by the invention is low in cost, mild in reaction condition and low in energy consumption, and avoids emission of three wastes; and the obtained product is high in load rate and good in environmental compatibility, and has a relatively long lasting period, the problem of burst release of pesticides in certain carriers is solved, the times of pesticide application is reduced, and the utilization ratio of the pesticides is improved.

Description

technical field [0001] The invention relates to a nano silicon dioxide grafted organic functional macromolecule macrolide insecticide sustained-release agent and a preparation method thereof, belonging to the technical field of new formulations of insecticides. Background technique [0002] In 2014, the production of chemical pesticides in my country reached 3.7 million tons, and the usage was close to 2 million tons. The long-term large-scale and low-efficiency application of pesticides (the effective utilization rate is only 10%-30%, and its loss rate is as high as 70%-90%) has caused the pesticide residues in my country's vegetables, fruits, grains, soil, and water to exceed the standard. The target organisms and human health pose a serious threat, which also leads to the destruction of the structure and function of the ecosystem. [0003] At present, the pesticide preparations produced and used in my country are mainly conventional pesticide formulations such as emulsifi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/08A01N25/10A01N43/90A01N43/22
CPCA01N25/08A01N25/10A01N43/22A01N43/90
Inventor 何顺李建洪万虎马洪菊高云昊沙黑拉什·拉马赞张小磊
Owner HUAZHONG AGRI UNIV
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