Single-cell subnanoscale motion control system based on nanoscale micromanipulation

Abstract

Disclosed in the invention is a nanometer-level-microoperation-based unicellular sub-nanometer-level motion control system. A microoperation platform is fixed on an objective table of a microscope; a first switching board is fixed on the microoperation platform; and a single-shaft sub-nanometer-level positioning system is fixed on the surface of the first switching board. An upper end of a second switching board is connected to the side surface of the single-shaft sub-nanometer-level positioning system; a probe clamping device clamp is fixed at a lower end of the second switching board; and a probe clamp with a probe installed at the front end is clamped in a spring clamp groove of the probe clamping device clamp. The probe arranged at the front end of the probe clamp is processed by opening according to the design demand; and cells near the pointed end of the probe are absorbed or released based on a positive pressure or negative pressure provided by the rear end of the probe clamp. According to the invention, the three-shaft precision can reach 7nm, the control range can be to 20nm, and the damages on living cells are low; the motion control precision is high and the closed ring precision can reach 0.05 nm; and because of the small three-dimensional size of the microoperation platform, the space of the objective table is saved and integration of the table to other complicated experiment systems can be realized easily.

Description

technical field [0001] The invention relates to a single-cell motion control system, in particular to a single-cell sub-nanometer motion control system based on nanoscale micromanipulation. Background technique [0002] The combination of engineering and biomedicine can solve many problems that cannot be solved by traditional biological methods. It is an important way to combine engineering and biomedicine to apply the methods of research problems in the field of engineering to the research of biology. With the development of biophysical methods in recent years, many novel and efficient methods have gradually become important tools in biomedical research. There are often no integrated products in the market for these emerging systems, but users can skillfully integrate the formed sub-modules into the new system according to their needs. [0003] The control of cell movement is the basis of many research methods in the field of biomechanics, but the complete precise control ...

AI Technical Summary

Problems solved by technology

At present, there are few formed single-cell motion control systems on the market, especially as sub-modules, single-cell motion control systems that can be easily and conveniently integrated into new systems are even rarer

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