Oligomers with improved off-target profile

Abstract

The present invention provides oligomers that binds RNA that consists of a lower affinity region and a higher affinity region, wherein the monomers in the higher affinity region increases the melting temperature (i.e. affinity) of the oligomer base paired to RNA more than the monomers used in the lower affinity region, wherein said increase in melting temperature is relatively to the alternative use of DNA monomers of the same (base) sequence. The oligomers of the invention are useful for binding to target RNA such as mRNA and non-coding RNA and have the advantage that they will be less prone to off-target binding via the lower affinity region than via the higher affinity region.

Description

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AI Technical Summary

Benefits of technology

This patented technology allows for better binding between specific parts (messenger ribonucleic acid or other nucleic acids) called targets by creating smaller molecules with fewer atoms at their edges compared to those nearer towards them. These small molecules are less likely to get stuck into certain areas where there's no activity needed during researches on these regions.

Problems solved by technology

This patent describes how certain types of molecules called small interferons regulated gene expression through specific interactions between them. These tiny interference factors help control important genes involved in various diseases like cancer cells. They work together specifically against each other's targets - either directly or indirectly related ones. By controlling these processes, we aimed at developing new drugs capable of effectively treating disease caused by abnormalities involving protein production.

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