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Application of Dianbaizhu in preparation of medicine for treating and/or preventing gastric ulcer

A technology of gastric ulcer and Dianbaizhu, applied in the application field of Dianbaizhu in the preparation of medicines for the treatment and/or prevention of gastric ulcer, to achieve the effect of reducing the total acidity of gastric juice, less pollution, and reducing the incidence of gastric ulcer in rats

Active Publication Date: 2019-05-17
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing literature shows that Baizhu Dianbai or its congeners have pharmacological activities such as anti-inflammatory, antibacterial, analgesic, expectorant, blood stasis and antitumor, but there is no literature report on the anti-gastric ulcer effect

Method used

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  • Application of Dianbaizhu in preparation of medicine for treating and/or preventing gastric ulcer
  • Application of Dianbaizhu in preparation of medicine for treating and/or preventing gastric ulcer
  • Application of Dianbaizhu in preparation of medicine for treating and/or preventing gastric ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] a. Take 1 kg of Dianbaiba medicinal material, crush and sieve, soak in 30% ethanol equivalent to 10 times the weight of the medicinal material for 0.5 h, heat and reflux for extraction for 1 h, and filter;

[0040] b. adding 30% ethanol equivalent to 8 times the weight of the medicinal material to the medicinal residue filtered in step a, heating and refluxing for 1 hour, and filtering;

[0041] c. adding 30% ethanol equivalent to 4 times the weight of the medicinal material to the medicinal residue filtered in step b, heating and refluxing for 1 hour, and filtering;

[0042] d. Combine the filtrates obtained in steps a, b, and c, recover the ethanol until it has no alcohol smell, and then concentrate it in a water bath to form a paste, so as to obtain the ethanol extract of Baizhu Diannan.

Embodiment 2

[0044] a. Take 1 kg of Dianbaiba medicinal material, crush and sieve, soak for 3 hours in absolute ethanol equivalent to 5 times the weight of the medicinal material, heat and reflux for extraction for 3 hours, and filter;

[0045] b. adding dehydrated ethanol equivalent to 3 times the weight of the medicinal material to the medicinal residue filtered in step a, heating and refluxing for extraction for 3 hours, and filtering;

[0046] c. adding dehydrated ethanol equivalent to 4 times the weight of medicinal materials to the medicinal residues filtered in step b, heating and refluxing for extraction for 3 hours, and filtering;

[0047] d. Combine the filtrates obtained in steps a, b, and c, recover the ethanol until it has no alcohol smell, and then concentrate it in a water bath to form a paste, so as to obtain the ethanol extract of Baizhu Diannan.

Embodiment 3

[0049] a. Take 1 kg of white pearl medicinal material, crush and sieve, soak in 95% ethanol equivalent to 8 times the weight of the medicinal material for 1.5 hours, heat and reflux for extraction for 1.5 hours, and filter;

[0050] b. adding 95% ethanol equivalent to 7 times the weight of medicinal materials to the medicinal residues filtered in step a, heating and refluxing for 1.5 hours, and filtering;

[0051] c. adding 95% ethanol equivalent to 5 times the weight of the medicinal material to the medicinal residue filtered in step b, heating and refluxing for 1.5 hours, and filtering;

[0052] d. Combine the filtrates obtained in steps a, b, and c, recover the ethanol until it has no alcohol smell, and then concentrate it in a water bath to form a paste, so as to obtain the ethanol extract of Baizhu Diannan.

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Abstract

The invention discloses the application of white pearl yunnanensis in the preparation of medicine for treating gastric ulcer, in particular the new application of white pearl yunnanensis extract in the preparation of medicine for treating and / or preventing gastric ulcer.

Description

technical field [0001] The present invention relates to the new application of Dianbaizhu, that is, the application in the preparation of medicines for treating and / or preventing gastric ulcer. Background technique [0002] Gastric ulcer is a common clinical chronic digestive system disease, mostly caused by acute indigestion, gastric bleeding, Helicobacter pylori infection, improper use of non-steroidal anti-inflammatory drugs and excessive mental stress, manifested as local tissue erosion of gastric mucosa , necrosis, or self-digestion, forming ulcers, and severe gastric perforation. The pathogenesis of gastric ulcer is not yet fully understood, and it is generally believed that it is related to gastric mucosal invasion factors (pepsin, hydrochloric acid, etc.) Integrity, cell regeneration, etc.) Gastric ulcer has a high incidence rate, slow healing, and easy recurrence, and a small number of patients with gastric ulcer can develop into gastric cancer, which seriously af...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/45A61P1/04
Inventor 何飞韦桂宁苏华
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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