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A traditional Chinese medicine composition for treating heart failure and cardiac autonomic neuropathy

A technology for autonomic neuropathy and heart failure, applied to the traditional Chinese medicine composition of cardiac autonomic neuropathy, in the field of treatment of heart failure, can solve the problems that diabetic neuropathy cannot be reversed, the disease cannot be cured, and the balance of autonomic nerves cannot be maintained or adjusted. , to achieve the effect of maintaining cardiac sympathetic-vagal balance, improving cardiac function and heart rate variability, and regulating cardiac autonomic nerve function

Active Publication Date: 2017-03-08
THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment methods for heart failure patients and cardiac autonomic neuropathy are relatively limited, and most of them start with improving heart failure and / or delaying neuropathy, which often cannot really treat the decline of cardiac autonomic nerve function and maintain the balance of cardiac autonomic nervous system. Poor, unable to achieve satisfactory therapeutic effect for patients
At present, Western medicine treats cardiac autonomic neuropathy mainly through the following points: 1) α-lipoic acid, which delays the progress of autonomic neuropathy; 2) Methylcobalamin, a derivative of vitamin B12, can stimulate the protein synthesis of nerve membrane cells, improve Nerve conduction velocity; 3) Aldose reductase inhibitory drugs, by delaying but not reversing the progression of diabetic neuropathy; 4) Angiotensin converting enzyme inhibitor (ACEI) drugs can also improve cardiac autonomic neuropathy, can improve cardiac The activity of parasympathetic nerve; 5) β-receptor blockers, diuretics, digoxin and other drugs improve heart failure and heart function, thus affecting nerve function
The above drugs mainly delay the progression of the disease and protect the nerve function. They cannot maintain or regulate the balance of the autonomic nervous system, and cannot cure the disease.

Method used

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  • A traditional Chinese medicine composition for treating heart failure and cardiac autonomic neuropathy
  • A traditional Chinese medicine composition for treating heart failure and cardiac autonomic neuropathy
  • A traditional Chinese medicine composition for treating heart failure and cardiac autonomic neuropathy

Examples

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Effect test

Embodiment 1

[0149] Meng, male, 61 years old, went to a local hospital in 2007 due to "chest tightness and shortness of breath". He underwent cardiac color Doppler ultrasound, which revealed dilated cardiomyopathy. The patient ignored it and did not take medication. The patient had a history of hypertension for more than 20 years, coronary heart disease for more than 10 years, and arrhythmia for more than 5 years. Since 2010, the patient has been admitted to the hospital many times for treatment. Before and after admission, he was given Xinxianan and L-carnitine into the polarization solution group to nourish the myocardium, improve myocardial metabolism, relieve blood circulation, activate blood circulation and remove blood stasis, torasemide and furosemide Static push for diuresis, digoxin enhances myocardial contractility, betaloc reduces myocardial oxygen consumption, lowers heart rate, delays the progress of heart failure, Lodinsin and Baixintong control blood pressure, aspirin anti-pl...

Embodiment 2

[0159] Zhao, female, 65 years old, was hospitalized in a local hospital in 2008 due to "palpitation, chest tightness, and shortness of breath". She was given cardiotonic, diuretic, and vasodilator treatments. Cardiac color Doppler ultrasound suggested dilated cardiomyopathy, but the patient ignored it and did not receive treatment. The patient had a history of hypertension for more than 10 years, coronary heart disease for more than 10 years, and arrhythmia for 3 years. The patient usually self-administered digoxin to enhance myocardial contractility, Diovan to control blood pressure, Betaloc sustained-release tablets to lower heart rate and reduce myocardial oxygen consumption, aspirin to prevent platelet aggregation, and Ruizhi to regulate blood lipids.

[0160] First consultation on March 4, 2013: The patient developed chest tightness, palpitation, and wheezing due to overwork, especially at night, which aggravated after activities, unable to lie down, coughing, abdominal d...

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Abstract

The invention provides a traditional Chinese medicine composition for treating heart failure and cardiovascular autonomic neuropathy and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition comprises 15-30g of pilose asiabell root, 20-30g of radix astragali, 10-15g of cassia twig, 10-15g of white peony root, 20-30g of tuber of dwarf lilyturf, 15-20g of bighead atractylodes rhizome and 6-9g of licorice root. The traditional Chinese medicine composition has functions of invigorating energy and nourishing heart, regulating ying and wei, improving heart functions, keeping heart sympathetic nerve-pneumogastric nerve balance, substantially improving heart functions and heart rate variability and adjusting heart nerve functions and is especially suitable for patients suffering from yin-wei disharmony-type cardiovascular autonomic neuropathy.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine composition for treating heart failure and cardiac autonomic neuropathy. Background technique [0002] Heart failure is the terminal state of many heart diseases, and the 5-year survival rate is similar to that of malignant tumors. The mortality rate of patients with cardiac function grade IV (NYHA classification) can reach 40% to 50%, and the 5-year mortality rate of patients with uncontrolled heart failure can reach 62%. Cardiac autonomic neuropathy is a common complication that can be seen in various heart diseases and diabetes. In heart failure, not only cardiomyocytes are necrotic and remodeled, but the autonomic nerves of the heart are also damaged. Damage to the autonomic nerves of the heart can aggravate the progression and severity of heart failure, and seriously affect the prognosis and quality of life of patients. Clinically, it...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61P9/04A61P25/00
Inventor 李晓姜萍杨金龙
Owner THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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