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Nutritional composition for improving muscle function and daily activity

A nutritional composition and functional technology, applied in the field of compositions for improving muscle function of mammals and compositions for improving daily activities of mammals

Inactive Publication Date: 2014-09-03
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in the latter, the supplementation period was only 2 weeks and / or included only a small number of patients

Method used

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  • Nutritional composition for improving muscle function and daily activity
  • Nutritional composition for improving muscle function and daily activity
  • Nutritional composition for improving muscle function and daily activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0171] Materials and methods

[0172] Animals. 6-7 week old male CD2F1 mice (BALB / c x DBA / 2, Harlan / Charles River the Netherlands). After one week of acclimatization, the mice were divided into weight-matched groups: (1) a control group receiving a control diet, (2) a tumor-bearing group receiving a control diet, and (3) a tumor-bearing group receiving an experimental diet. The data presented are derived from the combination of several experimental trials with identical animal characteristics and experimental procedures (unless otherwise stated) and differing only in the experimental food used. All experimental procedures were approved by the Animal Ethical Committee (DEC consult, Bilthoven, The Netherlands) and followed principles of good laboratory animal care.

[0173] Experimental foods (category A and B experiments). Experiments were divided into: (A) designed to test nutritional components added to a background diet (AIN93-M) and supplied as pellets (addition of high ...

example 2

[0206] Example 2: Recipe Example

[0207] The sip feed may specifically comprise macronutrients within the ranges specified in Table 3. Specific examples are given in Table 4. Additionally, one or more micronutrients (eg, minerals, vitamins, etc.) and / or one or more other food-grade additives (eg, flavoring agents, preservatives, non-protein amino acids such as carnitine) may be present.

[0208] Table 3: Nutritional composition of sipping feed (per 100ml)

[0209] Protein substance (equivalent) (g)

9–12

-Contains total whey protein

1–9

- Contains total leucine (g)

1.5–2.5

-Leucine is a free amino acid (g)

0.9–1.5

Carbohydrates (g)

10–25

Fat (g)

2–6

- unsaturated fats

2–6

-Omega 3 polyunsaturated fats

0.8–2

- Among them, EPA, DHA, ETA, DPA

0.2–2

Soluble fat, food g

1–4

[0210] Table 4: Nutritional composition of sipping feed (per 100ml)

[0211] P...

example 3

[0222] Example 3: Myosin synthesis in colorectal cancer patients following nutritional supplementation

[0223] Sipping feeds from possible compositions containing specific nutrient combinations as described in Table 4 were tested for their ability to affect the rate of muscle protein synthesis and compared to a control product described in Table 8.

[0224] Table 8. Supplement Composition

[0225]

[0226] *SNC: 2.9g whey protein, 1.1g free leucine, balanced casein, control casein only

[0227] Research Design and Methods

[0228] Study Subjects. Enroll subjects based on the inclusion / exclusion criteria described below. All subjects were able to walk, sit and stand independently. Prior to this study, screening procedures were not performed in the context of cancer care. A total of 24 subjects (12 per group) completed the protocol. The inclusion criteria were as follows: (1) radiographic evidence of cancer, (2) age >40 years (male and female), (3) ability to give infor...

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Abstract

The invention relates to a nutritional composition comprising (a) at least 18 en % of proteinaceous matter, said proteinaceous matter comprising whey; (b) at least 12 wt % of leucine, based on total proteinaceous matter; and (c) a lipid fraction comprising at least a [omega]-3 polyunsaturated fatty acid selected from the group of eicosapentaenoic acid, docosahexaenoic acid, eicosatetraenoic acid and docosapentaenoic acid for improving the muscle function in a mammal, for improving daily activity, for improving physical performance, for providing a better prognosis in terms of extended life-expectancy, for improving compliance to an anti-cancer therapy or for improving a quality of life.

Description

[0001] This application is a divisional application of Chinese Patent Application No. 200980134296.3 entitled "Nutritional Composition for Improving Muscle Function and Daily Activities" with the filing date of July 2, 2009. technical field [0002] The present invention relates to a composition comprising a proteinaceous substance comprising leucine and omega-3 polyunsaturated fatty acids. [0003] The invention also relates to the use of a composition suitable for improving muscle function in mammals. The invention also relates to the use of compositions suitable for improving the daily activities of mammals. Background technique [0004] Body composition, muscle function and daily activity are clinically highly relevant parameters, as muscle function and daily activity are important contributors to quality of life in cancer patients. Furthermore, improvements in a patient's physical condition, as reflected by body composition and physical performance, may contribute to i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/305A23L33/00
CPCA23L1/3056A23V2002/00A23L1/296A23L1/3051A23L1/3008A23L33/12A23L33/175A23L33/10A23L33/17A23V2200/30A23V2200/308A23V2250/21A23L33/19A61K31/145A61K31/198A61K31/202A61K31/205A61K31/702A61P21/00A23V2200/316A23V2250/54252A23V2250/54246A23V2250/0628A23V2250/062A23V2250/0616A23V2250/063A23V2250/1862A23V2250/187A23V2250/1868A23V2250/1872A23V2250/0612A23V2250/0644A23L33/40A61K35/20
Inventor 克拉斯克·范诺伦阿德里安乌斯·拉姆贝图斯·贝特霍尔德斯·范赫尔福尔特霍伊塞·法贝尔罗伯特·约翰·约瑟夫·哈格曼阿简·保罗·福斯
Owner NV NUTRICIA
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