Preparation method and application of quaternary ammonium epoxy siloxane particles

The technology of epoxy siloxane and propyl trimethoxy silane is applied in the field of preparation of quaternary ammonium epoxy siloxane particles, which can solve problems such as blanks in research work and achieve the effect of preventing bacterial re-infection

Inactive Publication Date: 2014-08-27
TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research work on the design and synthesis of oral antibacterial drugs that can be polymerized with epoxy resin materials is still blank at home and abroad.

Method used

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  • Preparation method and application of quaternary ammonium epoxy siloxane particles
  • Preparation method and application of quaternary ammonium epoxy siloxane particles
  • Preparation method and application of quaternary ammonium epoxy siloxane particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A kind of preparation method of quaternary ammonium epoxy group siloxane particle, it comprises the following steps:

[0033] The reaction precursors are: tetraethylorthosilicate (TEOS), γ-glycidyl etheroxypropyltrimethoxysilane (3-GPTS), dimethyloctadecyl[3-(trimethoxysilane base) propyl] ammonium chloride (SiQAC).

[0034] 1) Mix TEOS, 3-GPTS and SiQAC according to the molar ratio of 9:1:1, take 5mL of the mixture and add it into a reaction vessel containing 40mL of ethanol (100%) and 100mL of ultrapure water, stir well, and then 0.7mL of hydrochloric acid (2M), stirred at 1200rpm with a magnetic rod for 1.5min;

[0035] 2) Add 1.4mL sodium hydroxide (2M) solution to the reaction vessel, and reduce the speed of the magnetic rod to 350rpm. Slowing down the stirring speed in this way is beneficial to control the uniformity of the particle size and diameter of the precipitated product, and the reaction is maintained for 2 hours;

[0036] 3) The solid precipitate obtain...

Embodiment 2

[0038] A kind of preparation method of quaternary ammonium epoxy group siloxane particle, it comprises the following steps:

[0039] 1) Mix TEOS, 3-GPTS and SiQAC according to the molar ratio of 12:2:1, take 10mL of the mixture and add it into a reaction vessel containing 80mL of ethanol (100%) and 160mL of ultrapure water, stir well, and then Add 1.2mL of hydrochloric acid (2M), and stir for 2min at a magnetic bar at 1200rpm;

[0040] 2) Add 2.5mL sodium hydroxide (2M) solution to the reaction vessel, and reduce the speed of the magnetic rod to 320rpm. Slowing down the stirring speed in this way is beneficial to control the uniformity of the particle size and diameter of the precipitated product, and the reaction is maintained for 2 hours;

[0041] 3) The solid precipitate obtained by the reaction is centrifuged to harvest the particle precipitate, which is repeatedly cleaned with ethanol, and then vacuum-dried to obtain the quaternary ammonium epoxy siloxane particle.

Embodiment 3

[0043] A kind of preparation method of quaternary ammonium epoxy group siloxane particle, it comprises the following steps:

[0044] 1) Mix TEOS, 3-GPTS and SiQAC according to the molar ratio of 15︰4︰1, take 10mL of the mixture and add it into a reaction vessel containing 100mL ethanol (100%) and 150mL ultrapure water, stir well, and then 1.5mL of hydrochloric acid (2M), stirred at a magnetic bar at 1200rpm for 2min;

[0045] 2) Add 3.0mL sodium hydroxide (2M) solution to the reaction vessel, and reduce the speed of the magnetic bar to 320rpm, so that the stirring speed is slowed down, which is beneficial to control the uniformity of the particle size and diameter of the precipitated product, and the reaction is maintained for 2 hours;

[0046] 3) The solid precipitate obtained by the reaction is centrifuged to harvest the particle precipitate, which is repeatedly cleaned with ethanol, and then vacuum-dried to obtain the quaternary ammonium epoxy siloxane particle.

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Abstract

The invention discloses a preparation method and an application of quaternary ammonium epoxy siloxane particles. The preparation method comprises the following steps: 1, adding tetraethyl orthosilicate, gamma-glycidoxypropyltrimethoxysilane and dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride to a reaction container containing ethanol, fully dissolving, adding dilute hydrochloric acid, and reacting for 1-5min; 2, adding a sodium hydroxide solution to the reaction container, and reacting under stirring for 1-3h; and 3, centrifuging solids obtained after the reaction in step 2, and drying. The quaternary ammonium epoxy siloxane particles can be applied in oral antibiotic medicines. Quaternary ammonium epoxy siloxane obtained in the invention endows an epoxy resin material with non-release durable antibiotic performance, can kill bacteria residual on the root canal in the root canal treatment process, and has a bacterium reinfection prevention effect after treatment.

Description

technical field [0001] The invention belongs to the technical field of medical drugs, and specifically refers to a preparation method and application of quaternary ammonium epoxy siloxane particles. Background technique [0002] The standard treatment for infected pulp due to trauma, dental caries, periodontal disease, etc. is root canal therapy. With the advent of aging in our country, root canal treatment has gradually become the most common medical activity in stomatology in our country. The root canal treatment process includes root canal preparation, irrigation, sealing medicine, and filling. The ultimate goal is to completely eliminate infection during the treatment process and to fill tightly to prevent microbial reinfection. Unfortunately, the success rate of root canal treatment is not as good as expected. Nearly half of all teeth that undergo root canal treatment may experience symptoms again, necessitating retreatment of the root canal. Scholars pointed out tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G77/26C08G77/14A61K31/80A61P31/04A61P1/02
Inventor 龚士强周彬毛靖
Owner TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH
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