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Medical food for cognitive decline

A technology of dietary supplements and compositions, applied in the field of medical food for cognitive decline, capable of solving problems such as microtubule instability and inability to combine

Inactive Publication Date: 2014-04-16
RGT UNIV OF CALIFORNIA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when tau is hyperphosphorylated, it cannot bind, and microtubules become unstable and begin to divide

Method used

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  • Medical food for cognitive decline
  • Medical food for cognitive decline
  • Medical food for cognitive decline

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Experimental program
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Embodiment

[0065] It has been reported that fish oil rich in the omega 3 fatty acid DHA is not effective in treating mild to moderate Alzheimer's disease patients with extensive β-amyloid plaques and tangles. DHA has been shown to reduce β-amyloid accumulation, but in an animal model with β-amyloid and tangles (tau pathology), 3xAD transgenic mice, when pathology develops, over time , DHA seems to lose its efficacy. We found that fish oil alone was not sufficient to treat 3xAD Tg mice.

[0066] Fisetin, a natural flavonoid rich in strawberries, is neuroprotective and may improve cognitive function in various animal models, including aging mice and mice transgenic for β-amyloid plaque accumulation. We have tested 0.6% DHA alone, 500ppm fisetin alone, and combined DHA+fisetin delivered as food supplements (in chow) to elderly 3xAD Tg with combined amyloid and tau pathology mice. The studies described above were performed from approximately 9 months to 13-14 months of age. DHA+fisetin i...

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Abstract

Nutraceutical formulations that improve cognitive function in adults diagnosed with neurodegenerative disease are provided, which comprise a combination of fisetin and DHA.

Description

[0001] priority [0002] This application claims priority to US Provisional Patent Application 61 / 488,003, filed May 19, 2011. [0003] government rights [0004] This work was supported by the U.S. Department of Veterans Affairs, thus the Federal Government has certain rights in this invention. Background technique [0005] Alzheimer's disease (AD) is a degenerative disease of the brain. It is the leading cause of dementia in the elderly. AD patients have increased problems related to memory loss and intellectual function, which progress to the point where they fail as normal individuals. With loss of intellectual skills, patients present with personality changes, social misbehavior, and schizophrenia. AD is disastrous for victims and their families because there are currently no effective palliative or preventive treatments for the inevitable neurodegeneration. [0006] On a macroscopic level, the brains of people with AD are often smaller, sometimes weighing less than ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/35A61K31/20A61K31/23A61P25/00
CPCA23L1/0029A23V2002/00A61K31/202A61K31/353A23L1/3008A23L1/0026A61K31/352A23L1/3002A23L33/105A23L33/12A61P25/00A61P25/28A61P3/02A61P43/00A61K2300/00A23V2200/322A23V2250/1868A23V2250/2116
Inventor 格雷格·M.·科勒莎莉·A.·弗罗奇大卫·R.·舒伯特帕梅拉·A.·马赫
Owner RGT UNIV OF CALIFORNIA
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