Method for the production of labelled scaffolds, comprising at least one reactive fluorinated surfactant, and scaffold produced therewith

A surfactant, reactive technology, used in the field of tissue engineering and organ engineering scaffolds, can solve the problems of inhomogeneity, phase separation, poor solubility, etc.

Inactive Publication Date: 2011-11-23
KONINK PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] A disadvantage of highly fluorinated compounds is the poor solubility of these compounds in polymer mixtures commonly used in the preparation of tissue engineering scaffolds
This poor solubility leads to phase separation and non-uniform solutions for scaffold fabrication
[0010] Another disadvantage is the high evaporation rate of highly fluorinated compounds which often leads to complete evaporation of the fluorinated compounds during the processing of the polymer mixture into polymer fibers and finally into the scaffold itself
[0011] Combined, these two disadvantages lead to the formation of scaffolds for tissue and / or organ engineering without any fluorinated compounds

Method used

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  • Method for the production of labelled scaffolds, comprising at least one reactive fluorinated surfactant, and scaffold produced therewith
  • Method for the production of labelled scaffolds, comprising at least one reactive fluorinated surfactant, and scaffold produced therewith
  • Method for the production of labelled scaffolds, comprising at least one reactive fluorinated surfactant, and scaffold produced therewith

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Embodiment

[0140] To illustrate the essential features of the present invention, two polymer solutions were prepared for scaffold construction by electrospinning. Electrospinning is a simple method for producing ultrafine fibers from materials such as polymers, composites, and other materials. Capable of forming solid and hollow nanofibers. The fine fibers are prepared by uniaxial stretching of a viscoelastic jet obtained from a polymer solution or melt by applying a high voltage. The fibers are deposited on a flat surface and result in a complex network, which can then be shaped.

[0141] The first electrospinning solution contains perfluorooctyl bromide (PFOB) commonly used in the prior art. The second solution contained, in addition to PFOB, a small amount of the reactive fluorinated surfactant 2(N-ethylperfluorooctanesulfonamido)ethyl acrylate.

[0142] Electrospinning solution 1:

[0143]3.4 g of polycaprolactone was dissolved in 16.6 g of chloroform by stirring at room temperat...

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Abstract

The present invention is related to scaffolds for tissue engineering and organ engineering. More particularly, the present invention is related to a method for the production of a labelled scaffold for tissue and / or organ engineering comprising a reactive fluorinated surfactant, which serve as imaging label for medical imaging means, like CT, MRI, PET, scintigraphy and / or ultrasound imaging and the like.

Description

technical field [0001] The present invention relates to scaffolds for tissue engineering and organ engineering. More particularly, the present invention relates to methods for the manufacture of labeled scaffolds for tissue and / or organ engineering containing reactive fluorinated surfactants which are useful for medical imaging modalities such as CT, MRI, PET , scintigraphy and / or ultrasound imaging, etc., serve as imaging markers. technical background [0002] Regenerative medicine is an emerging field aimed at developing innovative medical treatments that will cause and allow the body to repair, restore and regenerate damaged or diseased cells, tissues and organs. Because they provide significant improvements in life expectancy and quality of life for a large number of chronically ill patients, therapeutic approaches based on principles of tissue regeneration will have strong clinical and economic impact. [0003] Tissue engineering is a relatively young discipline that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50
CPCA61L27/50
Inventor E.彼得斯D.哈尔特D.J.布罗德R.彭特曼
Owner KONINK PHILIPS ELECTRONICS NV
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