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Tumor antigen TRAG-3 mimotope peptide and application thereof

A TRAG-3, mimetic epitope technology, applied in the field of tumor antigen mimetic epitope peptides, can solve the problems of increasing the strength of CTL immune response and anti-peptidase degradation ability, and the natural epitope peptide is not easy to be taken up and easily degraded by peptidase. , to achieve good development and application prospects, strong CTL specific killing effect, strong affinity effect

Inactive Publication Date: 2012-08-15
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0005] However, natural epitope peptides are not easily taken up by antigen-presenting cells and easily degraded by peptidases. The tumor peptide vaccine based on them cannot meet the requirements of tumor immunotherapy. Natural epitope peptides must be modified to Increase the intensity of CTL immune response and resistance to peptidase degradation

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  • Tumor antigen TRAG-3 mimotope peptide and application thereof
  • Tumor antigen TRAG-3 mimotope peptide and application thereof
  • Tumor antigen TRAG-3 mimotope peptide and application thereof

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Embodiment Construction

[0022] Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. The experimental method that does not indicate specific conditions in the preferred embodiment is usually according to conventional conditions, such as described in the Molecular Cloning Experiment Guide (Third Edition, J. Sambrook et al., translated by Huang Peitang, etc., Science Press, 2002) conditions, or as recommended by the manufacturer.

[0023] 1. Sequences of candidate TRAG-3 mimotope peptides

[0024] TRAG-3 natural epitope peptide (TRAG-3 58-66 , ILLRDAGLV, the L-amino acids at each position in SEQ ID No.1) were individually replaced with the corresponding D-amino acids to obtain nine candidate TRAG-3 mimotope peptides.

[0025] 2. Molecular dynamics simulation of candidate TRAG-3 mimic epitope peptides

[0026] 1. Molecular model construction

[0027] Using Silicon graphics workstation and Discover 3.0 module in Insight II...

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Abstract

The invention discloses a tumor antigen TRAG-3 mimic epitope peptide and an application thereof. The mimic epitope peptide comprises an amino acid sequence shown by Ile-Leu-Leu-Arg-Asp-Ala-Gly-Leu-Val, wherein the fifth Asp is D-Asp or the sixth Ala is D-Ala. The mimic epitope peptide has the advantages of better enzymic degradation resistant stability compared with TRAG-3 natural epitope peptide, stronger appetency compared with HLA-A2.1, and stronger CTL specific killing effect compared with TRAG-3 positive tumor cells, can be used for preparing polypeptide vaccine for treating the TRAG-3 positive tumor cells, and has good development and application prospect in the immunotherapy filed.

Description

technical field [0001] The invention relates to a tumor antigen mimic epitope peptide, in particular to a tumor antigen TRAG-3 mimic epitope peptide, and also relates to the application of the mimic epitope peptide. Background technique [0002] Malignant tumors are diseases with high morbidity and high mortality that seriously threaten human health. Its treatment methods mainly include surgical resection, radiotherapy and chemical drug treatment, but the therapeutic effects of these methods on some tumors, especially advanced malignant tumors are not satisfactory. In recent years, tumor immunotherapy has developed rapidly as the fourth treatment method for malignant tumors. A large number of literatures have reported that tumor vaccines based on tumor antigen cytotoxic T lymphocyte (CTL) epitopes can effectively induce the production of specific tumor-killing CTLs in vivo, so that the disease of some patients can be controlled and alleviated, while it has no effect on norm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/06A61K39/00A61P35/00
Inventor 朱波林治华王槐亮龙海霞程晓明陈正堂
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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