X-ray developing calcium phosphate cement and preparation method and application thereof

A calcium phosphate bone cement and visualization technology, applied in medical science, prosthesis and other directions, can solve the problems of insufficient visualization, unfavorable injection and implantation process monitoring, etc., achieve good X-ray imaging effect, reduce surgical complications, improve effect of treatment

Active Publication Date: 2012-05-30
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Calcium phosphate bone cement is a bone defect repair material with good clinical application prospects, but at present, there is a problem of insufficient visualization when implanted into the body through percutaneous injection, which is not conducive to monitoring the injection implantation process through X-ray machines

Method used

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  • X-ray developing calcium phosphate cement and preparation method and application thereof
  • X-ray developing calcium phosphate cement and preparation method and application thereof
  • X-ray developing calcium phosphate cement and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of visualized calcium phosphate bone cement using bismuth phosphate as contrast agent:

[0028] (1) Add bismuth phosphate to α-tricalcium phosphate (α-TCP) + calcium hydrogen phosphate dihydrate (DCPD) + calcium carbonate (CaCO 3 ) + hydroxyapatite (HA) + magnesium phosphate (Mg 3 (PO 4 ) 2 )+sodium hydrogen phosphite (NaHSO3 ) system bone cement powder, in which the mass ratio of the developer (bismuth phosphate) to the bone cement powder is 15:100, using dry mixing, grinding in a ball mill for 5 hours, and then passing through a 400-mesh sieve to obtain X-ray Developable calcium phosphate bone cement powder;

[0029] (2) adding mass percentage concentration is that the disodium hydrogen phosphate of 3% and the mass percentage concentration are 0.02% sodium dihydrogen phosphate mixed solution as blending liquid, obtain by the liquid-solid ratio of 0.5mL / g and step (1) X After the light-developable calcium phosphate bone cement powder is fully mixed and ...

Embodiment 2

[0035] Preparation of developable calcium phosphate bone cement using bismuth aluminate as contrast agent:

[0036] (1) Add bismuth aluminate as a developer to the bone cement powder of the amorphous calcium phosphate (ACP) + calcium hydrogen phosphate dihydrate (DCPD) system, where the mass of the developer (bismuth aluminate) and bone cement powder The ratio is 9:100, using wet mixing method, adding ethanol according to the mass ratio of calcium phosphate bone cement powder and ethanol as 1:1, grinding in a ball mill for 2 hours, then drying in an oven at 60°C for 48 hours, and passing 200 mesh sieves to obtain X-ray imaging calcium phosphate bone cement powder;

[0037] (2) Add deionized water as the blending solution, according to the liquid-solid ratio of 0.3mL / g (that is, 1g of calcium phosphate bone cement solid powder plus 0.3mL of water) and the X-ray-developing calcium phosphate bone cement obtained in step (1) After the powder is mixed evenly, a calcium phosphate b...

Embodiment 3

[0043] Preparation of visualized calcium phosphate bone cement using bismuth silicate as contrast agent:

[0044] (1) Add bismuth silicate to tricalcium phosphate (TCP) + calcium hydrogen phosphate dihydrate (DCPD) system bone cement powder, wherein the mass ratio of developer (bismuth silicate) to bone cement powder is 10: 100, using dry mixing, grinding in a ball mill for 3 hours, and passing through a 300-mesh sieve to obtain the powder of X-ray-developing calcium phosphate bone cement;

[0045] (2) Use physiological saline as a concoction solution, mix evenly with the X-ray-developing calcium phosphate bone cement powder obtained in step (1) at a liquid-solid ratio of 0.5mL / g, and obtain X-ray-developing calcium phosphate bone cement powder cement paste.

[0046] The obtained X-ray-visible calcium phosphate bone cement paste is directly implanted into the surgical site through instruments for use, or it is formed into a solidified body in an in vitro human simulation envi...

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Abstract

The invention discloses X-ray developing calcium phosphate cement and a preparation method and application thereof. The method comprises the following steps: (1) adding a developer in calcium phosphate cement powder and carrying out dry mixing or wet mixing by adding organic dispersant for 0.5-5h, drying and sifting out to obtain the X-ray developing calcium phosphate cement powder; (2) evenly mixing hardening liquid and the X-ray developing calcium phosphate cement powder based on liquid-solid ratio of 0.3-0.6mL / g to obtain X-ray developing calcium phosphate cement paste. In the method, bismuth compound and iodide are successfully applied to the calcium phosphate cement as the developers for the first time, thus remarkably enhancing the developing property of the calcium phosphate cementwhile keeping intrinsic curing characteristic of the calcium phosphate cement, effectively improving the success ratios of operations and broadening the application prospect of the calcium phosphate cement.

Description

technical field [0001] The invention belongs to the field of medical materials for repairing bone defects, and in particular relates to an X-ray developing calcium phosphate bone cement and its preparation method and application. Background technique [0002] Calcium phosphate bone cement is composed of powder mixed with one or more calcium phosphate salts and a solidifying liquid. When used, the two are blended in a certain proportion. They can solidify and shape accurately at room temperature or in the environment of the human body. The reaction is finally mainly transformed into hydroxyapatite (HA), which can guide the growth of bone tissue, and is gradually absorbed by the tissue to produce bone tissue regeneration effect. It has good biocompatibility and has shown great clinical application in bone defect repair. and broad market prospects. In order to meet the clinical needs of minimally invasive surgery, in the surgical treatment of some bone defects and fractures, i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/50A61L27/02
Inventor 叶建东杨淑娥王迎军马强
Owner SOUTH CHINA UNIV OF TECH
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