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Combination s-nitrosothiol-based pharmaceutical products for restoring normal breathing rhythm

A technology of nitrosothiol and respiratory rhythm, applied in respiratory diseases, medical preparations containing active ingredients, pharmaceutical formulas, etc.

Inactive Publication Date: 2008-10-22
GALLEON PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is currently an unmet need for such products that can be administered to patients with minimal side effects

Method used

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  • Combination s-nitrosothiol-based pharmaceutical products for restoring normal breathing rhythm
  • Combination s-nitrosothiol-based pharmaceutical products for restoring normal breathing rhythm
  • Combination s-nitrosothiol-based pharmaceutical products for restoring normal breathing rhythm

Examples

Experimental program
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Embodiment 1

Embodiment 1: the method for analyzing compound composition

[0142] An established method for evaluating the effects of drugs acting on respiratory control is to create a closed system in which key factors affecting respiration can be tightly controlled and monitored. For example, control systems for oxygen concentration, carbon dioxide concentration, and atmospheric pressure are established.

[0143] For animal-based evaluation, systems are available that allow whole-body or nose-only evaluation of multiple respiratory function measurements. There are also established animal models (eg, guinea pigs, dogs, rodents) of breathing in combination with allergy, inflammation, COPD, and the use of narcotic analgesics. As a non-limiting example, the Lovelace Respiratory Research Institute (Albuquerque, NM) has extensive experience in developing these models as part of the evaluation of new drugs and for environmental exposure purposes.

[0144] A similar system has been established for...

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Abstract

The present invention is directed to a method of treating a lack of normal breathing control including the treatment of apnea and hypoventilation associated with sleep, obesity, certain medicines and other medical conditions. In an aspect, the invention is directed to treating disordered control of breathing by administering an composition comprising a combination of two or more compounds, at least one of which treats lack of normal breathing. In one aspect, a compound is an S-nitrosylating agent.

Description

S-Nitrosothiol-Based Compound Drugs for Restoration of Normal Respiratory Rhythm Background of the invention [0001] Normal respiratory control is a complex process that involves the body's interpretation and response to chemical stimuli such as carbon dioxide, pH and oxygen levels in the blood, tissues and brain. Breathing control is also affected by wakefulness (ie, whether the patient is awake or asleep). In the brain there is a breathing control center that interprets the various signals that affect breathing and sends commands to the muscles that perform the work of breathing. Important muscle groups are located in the abdomen, diaphragm, pharynx and chest. Centrally and peripherally located receptors then provide input to the central respiratory control area of ​​the brain, which is able to respond to changing oxygen demands. [0002] A normal respiratory rhythm is maintained primarily by the body's rapid response to changes in carbon dioxide (CO2) levels. Elevated CO2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/00
CPCA61K45/06A61K31/21A61P11/00A61P11/06A61P11/16A61P43/00A61K2300/00
Inventor J·G·曼尼恩
Owner GALLEON PHARMA INC
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