System and method for managing detrimental cardiac remodeling
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A technology for cardiac reconstruction and cardiac tissue, which can be used in cardiac stimulators, electrotherapy, therapy, etc., to solve the problems of unhealed tissue damaged by infarction.
Inactive Publication Date: 2007-11-21
MR3 MEDICAL LLC
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[0035] Although the use of drugs may be beneficial, after a myocardial infarction, undamaged areas of the heart still have to work harder and tissue damaged by the infarction remains unhealed
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[0077] Embodiments of the present invention provide a method for treating the heart after myocardial infarction (MI). Electrical stimulation was delivered to selected parts of the heart regardless of whether any arrhythmia diagnosis was made. Stimulation can be excitatory or non-excitable using cathodal, anodal and biphasic waveforms. The portion of the heart selected for stimulation is selected based on the type of stimulation performed and the degree of damage to the cardiac tissue. In an exemplary embodiment, only healthy heart tissue is stimulated.
[0078] In an exemplary embodiment of the invention, biphasic biventricular stimulation targets undamaged regions of the heart to enhance muscle contraction of healthy tissue, thereby allowing the heart to achieve normal or near normal function. The enhanced muscle contraction of the stimulating part of the heart reduces the load on the heart and prevents and reduces the unfavorable state of remodeling of the heart after myoc...
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Abstract
A system and method for managing and inhibiting cardiac remodeling in MI patients. Bi-ventricular stimulation is constantly provided with and without sensing to encourage normal pumping of the heart on a consistent basis. Pulses are administered using an anodal pulse followed by a cathodal pulse to stimulate cardiac muscle contraction. Stem cells are administered to MI areas to encourage regeneration of cardiac tissue in the damaged area. Stimulation may be provide to both healthy and compromised cardiac tissue.
Description
[0001] cross reference [0002] This application claims priority under U.S.C. § 119(e) from Provisional Application No. 60 / 575,121 filed May 28,2004. The 60 / 575,121 provisional application is hereby incorporated by reference in its entirety for all purposes. This application is a continuation-in-part of U.S. Patent Application Serial No. 10 / 053,750 filed January 21, 2002, which is pending, and U.S. Patent Application No. 09 / 690,947 A continuation-in-part of now U.S. Patent No. 6,341,235 which is a continuation-in-part of U.S. Patent Application No. 09 / 008,636 filed January 16, 1998, now U.S. Patent No. 6,136,019 which is US Patent Application No. 08 / 699,552 filed August 19, 1996 is now a continuation-in-part of US Patent No. 5,871,506. The 10 / 053,750, 09 / 690,947, 09 / 008,636 and 08 / 699,552 applications are hereby incorporated by reference in their entirety for all purposes. technical field [0003] The present application relates generally to cardiac related therapy, and mo...
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