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Program controlled feedback feeding-system for culturing cell

A technology of cell culture and feeding feedback, applied in the field of microcomputer control system, can solve problems such as patents and literature reports of complete sets of equipment that have not been seen

Active Publication Date: 2005-10-26
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0026] The present invention applies the classic PID control theory in principle, but in terms of system composition and hardware configuration, system optimization is carried out according to the characteristics of animal cell culture, and the current mature technologies such as computers, biochemical analyzers and peristaltic pumps are organically combined To meet the needs of large-scale high-density culture of animal cells, there are no patents and literature reports for complete sets of equipment at home and abroad

Method used

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  • Program controlled feedback feeding-system for culturing cell
  • Program controlled feedback feeding-system for culturing cell
  • Program controlled feedback feeding-system for culturing cell

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Embodiment Construction

[0042] (1) Composition of feedback control system

[0043] see figure 1 The feedback control system of the present invention includes: biochemical analyzer, 485 / 232 interface conversion module, communication port expansion card, computer and special control software, voltage output card, signal conditioning and driving circuit, peristaltic pump group and bioreactor .

[0044] (2) Basic principles applied to feedback control systems

[0045] PID Feedback Control Principle

[0046] Today's automatic control technology is based on the concept of feedback. The elements of feedback theory consist of three parts: measurement, comparison, and execution. Measure the variable of interest, compare it to the expected value, and use this error correction to adjust the response of the control system. The key to this theory and applied automatic control is how to better correct the system after making correct measurements and comparisons.

[0047] PID (proportional-integral-derivative...

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Abstract

The invention discloses a program controllable feedback replenishment system for culturing cells. This system is based on PID feedback control principle. Input biology chemistry analysis signal from PC communicating interface, and output at the responded interface after PC data disposing. It achieves to closed loop cooperation self-detect of biology chemistry analysis, creepage and biology actor, precisely feedback control of nutriment thickness in biology actor. The invention is characterized by stability, high control precision, process control index defined, high maneuverability and large applied range. It adapts to the producing of using animal cell expressing biology technology production and technics process research.

Description

technical field [0001] The invention relates to a microcomputer control system, and further relates to a microcomputer control system for controlling the concentration of nutrients in a bioreactor based on the feedback of a biochemical analyzer. Background technique [0002] The large-scale cultivation of animal cells has become one of the most important key technologies in the field of biopharmaceuticals, and the in-depth and progress of its research has promoted the rapid development of the biotechnology industry. [0003] The fed-batch culture process is the mainstream culture technology in the current animal cell culture technology, and it is also a hot spot in the large-scale cultivation of animal cells in recent years. [1] . Companies that choose to use Fed-batch in large-scale protein production include Genentech, IDEC, MedImmune, Merck, etc. in the United States. This process has the advantages of simple operation, high yield, and easy...

Claims

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Application Information

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IPC IPC(8): C12M3/00G06F19/00
Inventor 米力冯强李宁方陆军
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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