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Clinical condition evaluation new system for predicting one-year joint destruction progress of rheumatoid arthritis patient

An arthritis and rheumatoid technology, applied in the medical field, can solve problems such as joint erosion and damage, large indirect economic losses for patients, and failure to effectively prevent the progress of joint damage in RA patients, so as to avoid disability, reduce or block the progress of joint damage Effect

Pending Publication Date: 2019-08-16
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More than 70% of RA patients have joint erosion and destruction, about 90% of which occur in the first year of the disease, and 20% to 30% of patients lose their original working ability in the first 2 to 3 years of onset, and are directly used for RA every year The cost of treatment and the indirect economic loss caused by the disability of the patient's working ability are very huge
The above suggests that the disease activity score-based treatment recommended by the current guidelines cannot effectively prevent the progression of joint destruction in RA patients, especially those whose disease activity reaches the standard after treatment. There is an urgent need for new and more effective indicators to improve the RA disease assessment system in clinical practice. To guide therapy in order to more effectively reduce or block the progression of joint destruction in RA patients

Method used

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  • Clinical condition evaluation new system for predicting one-year joint destruction progress of rheumatoid arthritis patient
  • Clinical condition evaluation new system for predicting one-year joint destruction progress of rheumatoid arthritis patient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The determination of embodiment 1 new index extremity muscle index (ASMI)

[0025]1. Among RA patients who completed the standard treatment according to the guidelines and were followed up for 1 year, the baseline body composition index variables that could predict the progression of radiographic joint destruction in 1 year were screened, and the gender was corrected by univariate and multivariate logistic regression analysis. , age, disease duration, rheumatoid factor (RF) status, anti-cyclic citrullinated peptide antibody (ACPA) status, smoking status, DAS28-CRP, Stanford Health Assessment Questionnaire-Disability Index (HAQ-DI), imaging modified sharp score Baseline ASMI (OR=0.625, 95%CI: 0.423-0.925) and sarcopenia (OR=2.139, 95%CI: 1.221-3.747) were screened out after baseline indicators such as total score (mTSS) and accumulated medication within 1 year They are the predictors of 1-year radiographic joint destruction progression in RA patients, that is, after adju...

Embodiment 2

[0035] Example 2 A new system for evaluating the clinical condition of patients with rheumatoid arthritis for 1 year of joint destruction progress

[0036] A new clinical condition assessment system for predicting the progression of joint destruction in patients with rheumatoid arthritis within one year, including the clinical condition assessment system recommended by the guidelines, and the new indicator ASMI in Example 1.

[0037] According to the new system, the process of evaluating the clinical condition and guiding the treatment of patients with rheumatoid arthritis is shown as follows: figure 1 Shown: On the basis of the clinical condition evaluation system recommended by the guidelines, the baseline body composition analysis was performed on the overall RA patients, and the patients were divided into two groups: baseline sarcopenia and baseline non-sarcopenia, for patients with baseline non-sarcopenia After 3 months of treatment, the muscle changes were monitored, and...

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Abstract

The invention discloses a clinical condition evaluation new system for predicting a one-year joint destruction progress of a rheumatoid arthritis patient. According to the invention, a new index whichcan be used for predicting the one-year joint destruction progress of the rheumatoid arthritis patient is researched, namely a limb muscle index (ASMI), and the clinical condition evaluation new system for predicting the one-year joint destruction progress of the rheumatoid arthritis patient is established based on the limb muscle index. The system can accurately screen the high-risk patient, themiddle-risk patient and the low-risk patient in the one-year joint destruction progress earlier than prior art for nine months to one year, and different treatment plans are utilized for the high-risk patient, the middle-risk patient and the low-risk patient, thereby realizing intensive treatment of the high-risk patient and the middle-risk patient earlier for nine months to one year, guiding clinical medicine taking for more effectively reducing or blocking the joint destruction progress of the rheumatoid arthritis patient, preventing disability, and realizing important meaning and high value in treatment controlling and monitoring of rheumatoid arthritis.

Description

technical field [0001] The invention belongs to the field of medical technology. More specifically, it relates to a new clinical condition assessment system for predicting the 1-year progression of joint destruction in patients with rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is a common chronic disabling disease characterized by progressive joint destruction, and it is the leading cause of physical disability in women in my country (accounting for 9.4%, according to the results of the second national sample survey of disabled people) . More than 70% of RA patients have joint erosion and destruction, about 90% of which occur in the first year of the disease, and 20% to 30% of patients lose their original working ability in the first 2 to 3 years of onset, and are directly used for RA every year The cost of treatment and the indirect economic loss caused by the disability of the patient's working ability are very huge. Therefore, controllin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30
CPCG16H50/30
Inventor 戴冽莫颖倩郑东辉马剑达林建子
Owner SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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