Devices, systems and methods for mapping tissue oxygenation

An oxygenation and tissue technology, used in surgical instruments and medical imaging systems, to solve problems such as missed polyp diagnosis

Active Publication Date: 2021-03-12
SURGISENSE CORP
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

While colonoscopy can detect up to 95% of cancerous lesions, approximately 25% of the time polyps are missed even with current "enhanced endoscopy" techniques

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  • Devices, systems and methods for mapping tissue oxygenation
  • Devices, systems and methods for mapping tissue oxygenation
  • Devices, systems and methods for mapping tissue oxygenation

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Embodiment Construction

[0053]Tissue parameters can be measured by a variety of methods. One technique used by the present invention is to measure tissue oxygenation levels by exploiting the oxygen-dependent quenching of phosphorescence via systemically or locally injected phosphorescent oxygen-sensing molecular probes for oxygen measurement, as described in U.S. Patent No. .4,947,850, U.S. Patent No. 5,837,865, U.S. Patent No. 6,362,175, U.S. Patent No. 6,165,741, U.S. Patent No. 6,274,086, U.S. Patent No. 7,575,890 and U.S. Patent Application Publication No. 2013 / 0224874, the disclosure of which It is hereby incorporated by reference in its entirety. Phosphorescent oxygen sensing probes consist of a phosphorescent metalloporphyrin core encapsulated inside a hydrophobic dendrimer, which forms a barrier that isolates the chromophore from direct contact with the environment, controls oxygen diffusion, and enables control of the probe's dynamic range and sensitivity. Protective case. Metalloporphyrin...

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Abstract

Devices, systems and methods for generating an in vivo map of oxygenation measurements of biological tissues are provided. These may include surgical instruments and stand-alone imaging systems with combined oxygen sensing functionality. Oxygenation maps can be determined via fluorescence or phosphorescence lifetime imaging of injectable probes with oxygen-dependent optical responses. Probe configurations and methods and apparatus for injecting probes into tissue are provided. Methods and apparatus are provided for temperature compensation of temperature-dependent lifetime measurements to improve oxygenation measurement accuracy. Oxygen maps can be registered with visible light images to help assess tissue viability or locate abnormalities in tissue. The resulting oxygen images can be used in a variety of applications including, but not limited to, guiding surgical procedures such as colorectal resections using intraoperative sensing, enhanced endoscopy for identifying suspicious lesions during colonoscopy imaging, and external imaging of tissue, such as to assess peripheral vascular disease.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 61 / 975,742, filed April 5, 2014, and U.S. Provisional Patent Application No. 62 / 061,079, filed October 7, 2014, each of which in its entirety Incorporated herein by reference. [0003] government interest [0004] This invention was made in whole or in part with Government support under Grant CA153571 from the National Institutes of Health. The government has certain rights in this invention. technical field [0005] The present invention relates to surgical instruments and medical imaging systems, and molecular reagents used by the instruments and systems; in particular, to surgical instruments and imaging systems having sensors for detecting properties of biological tissue, and methods for utilizing information collected by the sensors system. The sensing system may be configured to obtain a map of physiological properties of tissue at mult...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B1/04A61B1/06
CPCA61B5/0071A61B5/0084A61B2560/0247A61B1/0005A61B1/018A61B1/043A61B1/0676A61B5/0035A61B5/015A61B5/14556A61B5/1459A61B1/000094A61B1/005A61B1/0125
Inventor J·M·赞德G·S·费斯切尔J·T·诺尔斯
Owner SURGISENSE CORP
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