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Lactobacillus reuteri DSM 17938 for the development of cognitive function

A technology of DSM17938, Lactobacillus reuteri, applied in the field of neuronal health

Inactive Publication Date: 2014-12-03
BIOGAIA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0027] To date, there have been no reports on the effects of probiotics on the development of brain cognitive function

Method used

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  • Lactobacillus reuteri DSM 17938 for the development of cognitive function
  • Lactobacillus reuteri DSM 17938 for the development of cognitive function
  • Lactobacillus reuteri DSM 17938 for the development of cognitive function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] The results of the experiments described in Example 1 demonstrate that administration of Lactobacillus reuteri promotes neuronal growth, survival, differentiation, plasticity in the cortex and hippocampus. Correct neural signaling is ensured by promoting myelination and neuronal plasticity. Thus, Lactobacillus reuteri administration supports the establishment of cognitive functions, in particular learning and memory, and thus mental performance.

[0143] Administration of Lactobacillus reuteri helps prevent and / or reduce the severity of impairment of cognitive function and / mood disturbances / disturbances.

[0144] Lactobacillus reuteri strains are probiotics isolated from the fecal microbiota of breastfed children. Thus, for health promotion strategies that attempt to mimic the microbiota of breastfed children as closely as possible, administration of Lactobacillus reuteri, especially to non-breastfed children, may provide than the advantages.

[0145] Example 1:

[...

Embodiment 2

[0165] Examples of the composition of infant formulas for use according to the invention are given below. The composition is given by way of example only. The protein source is a regular blend of whey and casein.

[0166]

[0167]

[0168] Lactobacillus reuteri L. reuteri DSM 17938 was deposited in the German DSM Microorganism Culture Collection on January 30, 2006.

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Abstract

The invention relates to Lactobacillus reuteri DSM 17938 for promoting the establishment of healthy and normal cognitive function in young mammals. In particular, the invention relates to the use of Lactobacillus reuteri DSM 17938 for promoting development of the brain structures responsible for cognitive functions (e.g. cortex and hippocampus) and its associated neural pathways and / or to reverse retardation and / or to prevent retardation of the establishment of cognitive functions. Humans or animals and, in particular, a foetus, pre- term or term born infant, toddler or child or a young adult may benefit from the invention.

Description

technical field [0001] The present invention relates generally to the fields of neuronal health, neuronal protection and neuronal development. The present invention specifically relates to the administration of probiotics capable of promoting the healthy establishment of cognitive function in infants, especially preterm, low, very low and very low birth weight infants. Background technique [0002] The nervous system is a highly complex network composed of neurons and glial cells. It is present in all mammalian species and consists of the central nervous system (brain and spinal cord) as well as the peripheral nervous system (somatic, autonomic and enteric nervous systems). [0003] The central nervous system (CNS), particularly the brain, drives cognitive functions. The cerebral cortex, the outermost layer of neural tissue of the mammalian brain, plays a key role in attention, perception, thought, language, higher cognition (executive functions), and information integrati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/30A61K35/74A61K35/747
CPCA23Y2220/71A61K2035/115A23V2002/00A61K35/747A23L1/3014A23L1/296A23L33/135A23L33/40A23V2400/11A23V2200/3204A23V2200/322A61P25/00A61P25/18A61P25/28A61P43/00A23V2400/173A61K35/74
Inventor 加芙列拉·贝尔贡齐立-德蒙马加利·福尔尼科尔·库施
Owner BIOGAIA AB
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