Traditional Chinese medicine composition for preventing and treating cardiac muscle fibers or myocardial hypertrophy

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating cardiac muscle fibers or myocardial hypertrophy. The traditional Chinese medicine composition is prepared from the following bulk pharmaceutical chemicals in parts by weights based on the traditional Chinese medicines: 50 to 30 parts of panax japonicus, 8 to 36 parts of fructus trichosanthis, 10 to 30 parts of kudzuvine root, 8 to 24 parts of ligusticum wallichii, and 6 to 28 parts of allium macrostemon. As the animal experiment and statistical analysis shown, after a rate subjected to cardiac muscle fibers or myocardial hypertrophy is given the traditional Chinese medicine composition, the full heart weight / body weight, cardiac ventricle weight / body weight, heart tissue inflammatory cells and cardiac muscle cell interstitial collagen are obviously reduced, the CVF (Collagen Volume Fraction) is obviously reduced, and therefore, that the composition has the effect of preventing and treating the cardiac muscle fibers or the myocardial hypertrophy is determined. The traditional Chinese medicine composition can be prepared into tablets, capsules, granules, oral liquid or injection together with pharmaceutically acceptable auxiliary materials.

Description

technical field [0001] The invention belongs to the field of clinical application of traditional Chinese medicine, and mainly relates to the application of a Chinese medicine composition in preventing and treating myocardial fibrosis or myocardial hypertrophy, and meanwhile, the invention also relates to a preparation method of the Chinese medicine composition. Background technique [0002] Myocardial fibrosis or myocardial hypertrophy is a kind of ventricular remodeling that occurs when the heart is overloaded for a long time. In addition to the deposition of connective tissue between myocardial cells, it is also accompanied by increased protein synthesis and cell volume in myocardial cells, which seriously affects the normal contraction and function of the heart. Diastolic function. Myocardial fibrosis or myocardial hypertrophy is a common complication and pathological basis of various cardiovascular diseases, such as hypertension, coronary heart disease, valvular heart di...

AI Technical Summary

Problems solved by technology

At present, among these drugs, only angiotensin-converting enzyme inhibitors have achieved a certain clinical therapeutic effect, but the effect is limited, and they cannot achieve very obvious anti-myocardial fibrosis or myocardial hypertrophy effects. There is no obvious evidence for other drugs so far. It can improve myocardial fibrosis or myocardial hypertrophy, so there is currently a lack of targeted and effective therapeutic drugs

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