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Polysaccharide-containing composition and lacrimal fluid layer-stabilizing instillation

A technology of polysaccharides and compositions, applied in the field of tear layer stabilization eye drops, which can solve the problems of not stabilizing the tear layer of the eyeball

Inactive Publication Date: 2006-12-13
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] So far, the pharmacological effects of polysaccharides, especially agar, have not been fully understood, and there is no idea of ​​using agar to stabilize the tear layer on the surface of the eyeball
In particular, no technique has been developed to stabilize tissues in contact with polysaccharide compositions consisting of agar and aqueous solvents by controlling the ratio of sol / gel components

Method used

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  • Polysaccharide-containing composition and lacrimal fluid layer-stabilizing instillation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Put 2.6 g of concentrated glycerin as an isotonic agent into a 100 ml flask, and add distilled water to make it 100 ml. Add 0.1 g of agar (AX-30: weight average molecular weight about 90,000) to this solution, heat, dissolve the agar at about 100°C, and cool to room temperature while stirring with a magnetic stirrer to obtain a slightly white Cloudy test solution 1 (viscosity: 2.9 mPas).

Embodiment 2

[0073] Except having used 0.01 g of agar (AX-30) instead of 0.1 g of agar (AX-30), it carried out similarly to Example 1, and obtained the transparent test solution 2 (viscosity: 1.1 mPas).

Embodiment 3

[0075] Add 0.5g of agar (UP-6: weight average molecular weight about 220,000) to 100ml of distilled water, heat, dissolve the agar at about 100°C, and then cool to room temperature while stirring with a magnetic stirrer to obtain a white turbid agar solution. Take 20ml of the agar solution obtained above, add 2.6g of concentrated glycerol therein, and add distilled water to 100ml to obtain a white turbid test solution 3 (viscosity: 1.5mPas).

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Abstract

An object of the present invention is to provide a composition which is excellent in safety and capable of dispersing uniformly on the mucous tissue when topically administered to mammals, and an ophthalmic soulution comprising the composition and capable of stabilizing the tear film and keeping the rear film on the eyeball surface snooth. In a composition comprising a polysaccharide, particularly agar, and water as essential components, an ophthalmic solution comprising the agar-containing composition of which an amount of precipitated agar after performing centrifugal separation at with 40,000 xg is less than 65 wt% of a total agar content has an excellent tear film stabilizing effect which was proved by a test on changes of corneal surface irregularity. Therefore, the agar-containing ophthalnic solution of the present invention has the effect of stabilizing the tear film on the eyeball surface over a prolonged period of time and is usable as an artificial tear fluid.

Description

technical field [0001] The present invention relates to a polysaccharide-containing composition and tear layer-stabilizing eye drops containing the composition. Background technique [0002] Various gels and thickeners composed of polysaccharides have been used in the fields of food, pharmaceuticals, cosmetics, cosmetics, etc., and a large number of gel and sol products have been marketed. In the above-mentioned fields, it is expected to develop a technology that can obtain hitherto unprecedented food texture, coating properties, biocompatibility, drug retention and pharmacological effects by strictly controlling the sol / gel state. [0003] Agar among polysaccharides has been widely used in food and other fields, and according to the Japanese Pharmacopoeia, it has high safety. In addition, agar is known to have a water-retaining effect that suppresses evaporation of water, so it is useful as a water-retaining agent for foods, pharmaceuticals, cosmetics, and the like. Recen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36G02C13/00A61K9/00
CPCA61K9/0048A61K47/36A61P27/02
Inventor 杉原由起子木村章男中村雅胤棚桥一裕荒木美帆谷口孝
Owner TORAY IND INC
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