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Antibacterial and anticoagulant coating material with super-hydrophilic capacity as well as preparation method and application of antibacterial and anticoagulant coating material

A coating material and super-hydrophilic technology, applied in the field of medical devices, can solve the problems of unclear molecular mechanism of PDA formation and adhesion, achieve good blood compatibility and antibacterial performance, improve anticoagulant antibacterial performance and Hydrophilic performance, good anticoagulant effect

Active Publication Date: 2022-07-22
WEST CHINA HOSPITAL SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The molecular mechanism of the formation and adhesion of PDA is still unclear

Method used

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  • Antibacterial and anticoagulant coating material with super-hydrophilic capacity as well as preparation method and application of antibacterial and anticoagulant coating material
  • Antibacterial and anticoagulant coating material with super-hydrophilic capacity as well as preparation method and application of antibacterial and anticoagulant coating material
  • Antibacterial and anticoagulant coating material with super-hydrophilic capacity as well as preparation method and application of antibacterial and anticoagulant coating material

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preparation example Construction

[0052] The preparation method of the antibacterial and anticoagulant coating material with super-hydrophilic ability comprises the following steps:

[0053] (1) adding the water-soluble zinc ion solution to the ammonia solution to produce a zinc-ammonium complex to form a zinc-ammonium solution;

[0054] (2) Dopamine is added to the zinc-ammonium solution obtained in step (1) to form a dopamine-zinc-ammonium solution, which is an antibacterial and anticoagulant coating material.

[0055] Wherein, in step (1), the concentration of the water-soluble zinc ion solution is 1 mol / L; preferably, the zinc chloride powder is put into ultrapure water to form a water-soluble zinc ion solution with a concentration of 1 mol / L.

[0056] Wherein, in step (1), the concentration of the ammonia solution is 4 mol / L; preferably, 25% ammonia solution is added to the ultrapure water to obtain an ammonia solution with a concentration of 4 mol / L.

[0057] Wherein, in step (1), the concentration of t...

Embodiment 1

[0068] The present embodiment provides an antibacterial and anticoagulant coating material with super-hydrophilic ability made from zinc chloride solution, ammonia water and dopamine, and the specific preparation method is as follows:

[0069] (1) the zinc chloride solution that concentration is 2mol / L is added to the ammonia solution that concentration is 6mol / L to produce zinc-ammonium complex, form zinc-ammonium solution;

[0070] (2) Dopamine is added to the zinc-ammonium solution obtained in step (1) to form a dopamine-zinc-ammonium solution, which is an antibacterial and anticoagulant coating material.

Embodiment 2

[0072] The present embodiment provides an antibacterial and anticoagulant coating material with super-hydrophilic ability made from the following raw materials and methods:

[0073] (1) put zinc nitrate powder into ultrapure water to form a zinc nitrate solution with a concentration of 1mol / L, add 25% ammonia water to the ultrapure water to obtain an ammonia solution with a concentration of 4mol / L; the concentration is 1mol / L The zinc nitrate solution was added to the ammonia solution with a concentration of 4 mol / L to produce a zinc-ammonium complex, forming a zinc-ammonium solution with a concentration of 0.05;

[0074] (2) Dopamine is added to the zinc-ammonium solution obtained in step (1) to form a dopamine-zinc-ammonium solution with a concentration of 0.2 mg / mL, which is an antibacterial and anticoagulant coating material.

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Abstract

The invention relates to an antibacterial and anticoagulant coating material with super-hydrophilic capacity as well as a preparation method and application thereof. The antibacterial and anticoagulant coating material is prepared from a zinc chloride solution, ammonia water and dopamine. The preparation method comprises the following steps: adding a soluble zinc ion solution into an ammonia water solution to generate a zinc-ammonium complex so as to form a zinc-ammonium solution; and adding dopamine to form a dopamine zinc ammonium solution, and reacting at room temperature for 24 hours to obtain the antibacterial and anticoagulant coating material. The antibacterial and anticoagulant coating material with the super-hydrophilic capacity has good blood compatibility, antibacterial performance and a certain anticoagulant effect, the antibacterial and anticoagulant coating material is of a honeycomb network structure in the microscopic aspect, and due to the spatial mesh structure, the antibacterial and anticoagulant coating material has super-high hydrophilicity.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to an antibacterial and anticoagulant coating material with super-hydrophilic capability and a preparation method and application thereof. Background technique [0002] Hemodialysis is an important renal replacement therapy for patients with acute and chronic renal failure. Among them, the central venous double-lumen catheter is a common blood catheter in hemodialysis technology. The blood in the human body is drawn out of the body through the outflow end of the catheter. After hemodialysis treatment, the blood is returned to the human body through the inflow end of the catheter to achieve the therapeutic effect. Because the catheter is immersed in the body, the catheter will rub against the wall tissue of the human body, which is easy to cause damage and even infection and edema, which makes the patient miserable. Therefore, how to reduce the friction between t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/16A61L29/14A61L29/06A61L29/10A61L29/08
CPCA61L29/16A61L29/14A61L29/06A61L29/106A61L29/085A61L2300/102A61L2300/404A61L2300/42A61L2300/606A61L2300/45A61L2300/216C08L75/04C08L79/04Y02A50/30
Inventor 张凌王坡刘壮刘晨
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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