Preparation and application for silver nanometer targeting tumor treatment system

A targeted therapy and silver nanotechnology, applied in the field of medicine, can solve the problems of unsatisfactory tumor treatment effect, large side effects of tumor treatment, high recurrence and metastasis rate, etc., and achieve the effect of enhancing tumor treatment effect, improving quality of life, and inhibiting tumor growth

Active Publication Date: 2020-06-26
GUANGXI MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the traditional tumor treatment effect is poor, the recurrence and metastasis rate is high, the side effects of tumor treatment are large, and the precision is poor, which leads to the unsatisfactory tumor treatment effect.

Method used

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  • Preparation and application for silver nanometer targeting tumor treatment system
  • Preparation and application for silver nanometer targeting tumor treatment system
  • Preparation and application for silver nanometer targeting tumor treatment system

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Embodiment 1

[0044]The silver nano-targeted tumor therapy system of the present invention includes composite nanomaterials containing PEAG@Ag NPs / rGO-Endoglin aptamer, wherein:

[0045] The PEAG is a guanidinium pegylated poly(2-aminoethylmethacrylate) polymer (PEG-b-PAEM-co-PGEM polymer); the Ag NPs are silver nanoparticles; the rGO is a reduced Graphene oxide; the rGO-Endoglin aptamer is a reduced graphene oxide-Endoglin aptamer conjugate.

[0046] 1. Preparation of PEAG@Ag NPs / rGO-Endoglin composite nanomaterials:

[0047] 1) Preparation of rGO solution. Dissolve 1 mg of graphene oxide (GO) in 1 mL of ultrapure water, sonicate for 6 h with a cell disruptor ultrasonicator, centrifuge at 3000 res / min to remove the precipitate, add 10 μL of hydrazine hydrate (NH2-NH2), vortex for 10 min, 60°C Water bath for 4 h, centrifuge at 10,000 rpm, remove supernatant, wash twice, disperse into 1 mg / mL reduced graphene oxide solution for later use, and obtain rGO solution;

[0048] 2) Prepare rGO-E...

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Abstract

The invention belongs to the field of medicines, and specifically relates to preparation and application for a silver nanometer targeting tumor treatment system. The silver nanometer targeting tumor treatment system comprises a composite nanometer material containing a PEAG@Ag NPs / rGO-Endoglin aptamer, wherein the PEAG is a guanidyl pegylated polymethylacrylic acid 2-aminoethyl ester polymer; Ag NPs are silver nanoparticles; and the rGO-Endoglin aptamer is a reduced graphene oxide-Endoglin aptamer conjugate. The preparation method comprises the following steps: 1) preparation of an rGO solution; (2) preparation of an rGO-Endoglin aptamer conjugate solution; (3) preparation of an Ag NPs / rGO-Endoglin aptamer solution; and (4) synthesis of PEAG@AgNPs / rGO-Endoglin. According to the invention,the Ag NPs are transported to a tumor site in a targeted manner, so the uptake effect of tumor cells to nanoparticles is improved; by utilization of the biological toxicity of the Ag nanoparticles, the treatment effect on tumor is realized and successfully tested on mice; the silver nanometer targeting tumor treatment system can be applied to anti-tumor clinical tests of the human body in the nextstep; and a good method is provided for anti-tumor clinical use of the human body.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the preparation and application of a silver nano-targeted tumor therapy system. Background technique [0002] Today, tumors have become the biggest threat to the life and health of Chinese residents, and the mortality rate of malignant tumors is gradually increasing, regardless of whether it is male or female. At present, the traditional tumor treatment effect is poor, the recurrence and metastasis rate is high, the side effects of tumor treatment are large, and the precision is poor, which leads to the unsatisfactory tumor treatment effect. Therefore, it is a key breakthrough point to improve the survival rate of patients to focus on cancer types with high incidence, characteristics and advantageous research foundation in my country, and to carry out corresponding targeted therapy for them. [0003] Silver nanoparticles (Ag NPs) are ultrafine particles formed by nanotechnolo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/60A61K47/54A61K33/38A61P35/00
CPCA61K47/6935A61K47/60A61K47/549A61K33/38A61P35/00Y02A50/30
Inventor 赵永祥黄渊余黄勇钟莉娉何坚
Owner GUANGXI MEDICAL UNIVERSITY
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